UCYGAGOHASJWLC-ACHOKTOGSA-L

Description

The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3)-P₁ (1,2-dioctanoyl) is a synthetic analog of natural PtdIns featuring C8:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and DAG stereochemistry as the natural compound. PtdIns-(3)-P₁ can be phosphorylated to di- (PtdIns-P₂; PIP₂) and triphosphates (PtdIns-P₃; PIP₃) by phosphatidyl inositol (PI)-specific kinases.

Uses

Glycerophospholipids act as regulators of various enzyme activities, and can be used as biological markers to indicate pathological states.

Uses

08:0 PI(3)P has been used in the preparation of model membrane for protein reconstitution and structural studies.

General Description

Phosphatidylinositol 3-monophosphate (PI3P) is a lipid, found abundantly in eukaryotic cells. It is also present at low level in mammalian cells.

Biochem/physiol Actions

Phosphatidylinositol 3-monophosphate (PI3P) participates in vesicular trafficking processes. It also plays a key role in endocytosis.