Description
The phosphatidylinositols (PtdIns) represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.1,2 PtdIns-(3,4)-P2 (1,2-dioctanoyl) is a synthetic analog of natural PtdIns featuring C8:0 fatty acids at the sn-1 and sn-2 positions. The compound contains the same inositol and diacylglycerol (DAG) stereochemistry as the natural compound. The natural compound is the product of phosphorylation-dephosphorylation involving PtdIn 3-kinase and 5-phosphatases. The 3D-phosphorylated PtdIns are resistant to hydrolysis by phospholipase C.3WARNING This product is not for human or veterinary use.
References
[1] MAJERUS P W. Inositol phosphate biochemistry.[J]. Annual review of biochemistry, 1992, 61: 225-250. DOI:
10.1146/annurev.bi.61.070192.001301[2] EXTON J H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins.[J]. Annual review of pharmacology and toxicology, 1996, 36: 481-509. DOI:
10.1146/annurev.pa.36.040196.002405[3] L A SERUNIAN. Polyphosphoinositides produced by phosphatidylinositol 3-kinase are poor substrates for phospholipases C from rat liver and bovine brain.[J]. The Journal of Biological Chemistry, 1989, 264 30: 17809-17815.
