Description
The phosphatidylinositol (PtdIns) represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.1,2 PtdIns is phosphorylated to mono- (PtdIns-P; PIP), di- (PtdIns-P2; PIP2) and triphosphates (PtdIns-P3; PIP3). Hydrolysis of PIP2 by PI-specific phospholipase C generates IP3 and diacylglycerol (DAG). The DAG and IP3 produced by this reaction are part of a complex biochemical and signal transduction cascade that is at the frontier of scientific research today.WARNING This product is not for human or veterinary use.
References
[1] EDUARDO G. LAPETINA P. C M M Billah. The phosphatidylinositol cycle and the regulation of arachidonic acid production[J]. Nature, 1981, 292 5821: 367-369. DOI:
10.1038/292367a0[2] MAJERUS P W. Inositol phosphate biochemistry.[J]. Annual review of biochemistry, 1992, 61: 225-250. DOI:
10.1146/annurev.bi.61.070192.001301
