The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3)-P1 (1,2-dioctanoyl) is a synthetic analog of natural PtdIns featuring C8:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and DAG stereochemistry as the natural compound. PtdIns-(3)-P1 can be phosphorylated to di- (PtdIns-P2; PIP2) and triphosphates (PtdIns-P3; PIP3) by phosphatidyl inositol (PI)-specific kinases.
Glycerophospholipids act as regulators of various enzyme activities, and can be used as biological markers to indicate pathological states.
08:0 PI(3)P has been used in the preparation of model membrane for protein reconstitution and structural studies.
Phosphatidylinositol 3-monophosphate (PI3P) is a lipid, found abundantly in eukaryotic cells. It is also present at low level in mammalian cells.
Phosphatidylinositol 3-monophosphate (PI3P) participates in vesicular trafficking processes. It also plays a key role in endocytosis.
