Description
2,2,6,6-
Tetramethylpiperidin-
1-
oxyl (TEMPO) is a stable radical that will react with reactive oxygen species (ROS). This conversion, followed by ESR, provides an indirect way to monitor ROS production in biological systems. TEMPONE is the 4-
oxo derivative of TEMPO. In addition to possible uses as a spin trap, this nitroxyl radical can be used in hydrogen transfer experiments and as a polarizing agent in dynamic nuclear polarization NMR spectroscopy. TEMPONE and other nitroxyl radicals have also been shown to reduce mean arterial pressure in spontaneously hypertensive rats when administered intravenously.
Chemical Properties
Pink Needles
Uses
Free-radical nitroxide spin probe typically used for:
- Redox sources for anodes in lithium secondary batteries
- Free-radical biological studies
- Radical spin-trapping
- Electron paramagnetic resonance studies
- Polymer chemisty and synthesis applications
Uses
A spin label for ESR studies
General Description
4-Oxo-TEMPO is formed by the reaction of 2,2,6,6-tetramethyl-4-piperidone (4-oxo-TMP) and
1O
2. It is a stable paramagnetic product formed during the irradiation of TiO
2 in aqueous suspensions.
Flammability and Explosibility
Non flammable
