Description
An alkaloid from Mahonia nepalensis DC. (Syn. Berberis nepalensis Spreng), this
base is optically inactive and forms garnet-red crystals which decompose on heat_x0002_ing. The base contains 3.5 mole of H20 and still retains 1 mole even or prolonged
drying at 100°C in vacuo. The salts are said to be orange or yellow.
Uses
Jatrorrhizine, is an alkaloid extract from the Berberidaceae family of plants displaying antioxidant activity.
Definition
ChEBI: Jatrorrhizine is an alkaloid.
in vivo
Jatrorrhizine (intraperitonealinjection; 5, 10, 20 mg/kg) can significantly reduce the duration of immobility when compared with vehicle control group in tail suspension test (TST)[2].
| Animal Model: | Male ICR albino mice[2] |
| Dosage: | 5, 10, 20 mg/kg |
| Administration: | Intraperitonealinjection; 5, 10, 20 mg/kg |
| Result: | Reduced immobility period in tail suspension test. |
target
LDL | P450 (e.g. CYP17) | NOS | COX | 5-HT Receptor | HMG-CoA Reductase
References
Chatterjee., Sci. & Cult., 7,619 (1942)
Chatterjee.,J. Amer. Pharm. Assoc., 33,205,210 (1944)
![2,9,10-Trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol Structure](https://www.chemicalbook.com/CAS/GIF/3621-38-3.gif)
