Chemical Properties
slightly yellow crystalline powder
Uses
6-Amino-1-hexanol can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1
H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.
Uses
6-Amino-1-hexanol is used as pharmaceutical intermediate.
Uses
6-Amino-1-hexanol is used in the synthesis of guanidino analogs of roscovitine, which is a cyclin-dependant kinase. Also used in the preparation of tocotrienols which maintain anticancer, antiprolifer
ative and antimigratory activity. Behery, F
Synthesis
By volume ratio, 1 part of 6-aminohexanoic acid was added to the reactor containing 15 parts of diethyl ether or dry toluene solution At 40 ℃ constant temperature, At 1500rpm / min speed, rapidly injected 2 parts of a solution of sodium borohydride. At 250W, ultrasonic treatment 20min. Then, dropwise under reflux, 8 parts of ethylene glycol solution. Dropwise addition time was 30 minutes. Finally, at 90 ℃ and at a rate of 800rpm/min, maintain temperature under stirring and react for 16 h to obtain the reaction crude product. (2) By the amount of parts count, step (1) preparation of 1 part of the reaction crude was added 6 parts water for hydrolysis. Undrego vacuum distillation, collecting 125 ℃ fraction, to obtain the 6-amino-1-hexanol product.
