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RESCINNAMINE

RESCINNAMINE Structure
RESCINNAMINE
  • CAS No.24815-24-5
  • Chemical Name:RESCINNAMINE
  • CBNumber:CB2344278
  • Molecular Formula:C35H42N2O9
  • Formula Weight:634.72
  • MOL File:24815-24-5.mol
RESCINNAMINE Property
  • Melting point: :238-239°C
  • alpha  :D24 -97° (c = 1 in chloroform)
  • Boiling point: :669.26°C (rough estimate)
  • Density  :1.2161 (rough estimate)
  • refractive index  :1.5300 (estimate)
  • storage temp.  :2-8°C
  • pka :pKa 6.4 (Uncertain)
  • Stability: :Stable, but darkens slowly in light. Incompatible with strong oxidizing agents.
  • CAS DataBase Reference :24815-24-5
  • FDA UNII :Q6W1F7DJ2D
  • ATC code :C02AA01
  • EPA Substance Registry System :Rescinnamine (24815-24-5)
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

RESCINNAMINE Chemical Properties,Usage,Production

  • Description This Rauwolfia alkaloid is found in the barks of R. serpentina and R. vomitora and was originally given the name Reserpinine, this being altered to avoid confusion with another alkaloid of the same name (q.v.). The base has [α]17D - 99.2° (c 1.3, CHCI3). From chemical degradation and spectroscopic analysis, the structure has been established as the 3:4: 5-trimethoxycinnamoyl ester of reserpic acid.
  • Chemical Properties white to cream powder
  • Uses Rescinnamine occurs in the roots of a num ber of Rauwolfia species. Therapeutically, itis used as an antihypertensive agent.
  • brand name Moderil (Pfizer).
  • General Description Odorless white to cream colored crystalline powder.
  • Air & Water Reactions Insoluble in water.
  • Reactivity Profile The neat material darkens slowly on exposure to light. In solution this occurs more rapidly. .
  • Health Hazard The pharmacological properties of rescinnamine are similar to those of reserpine, butthe side effects are low. It acts as a sedativeand hypotensive. A dose of 0.25 mg/day mayproduce the effect of sleepiness in humans.Excessive doses may produce depression,nightmare, nausea, diarrhea, and hypotension.
    LD50 value, oral (rats): 1000 mg/kg
    The carcinogenicity of rescinnamine inanimals or humans is unknown.
  • Fire Hazard Flash point data for RESCINNAMINE are not available. RESCINNAMINE is probably combustible.
  • Purification Methods Crystallise it from *benzene, MeOH or aqueous Me2CO. The hydrochloride has m 232o(dec) (from MeOH) and [] D -74o (MeOH). It is an antihypertensive. [Klohs et al. J Am Chem Soc 77 2241 1955, Beilstein 25 III/IV 1323.]
  • References Haack e tal., Naturwiss., 41, 214 (1954)
    Klohs, Draper, Keller.,J. Amer. Chem. Soc., 77,2241 (1955)
    Kidd., Chem. & Ind., 1481 (1955)
    Popelak, Lettenbauer., Arch. Pharm., 296,261 (1963)
RESCINNAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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24815-24-5, RESCINNAMINERelated Search:
  • Yohimban-16-carboxylic acid, 11,17-dimethoxy-18-[[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]oxy]-, methyl ester, (3β,16β,17α,18β,20α)-
  • METHYL RESERPATE-3,4,5-TRIMETHOXY CINNAMIC ACID ESTER
  • ANAPREL
  • 3,4,5-TRIMETHOXYCINNAMOYLRESERPATE
  • 17alpha-dimethoxy-18beta-((1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl)oxy)-1
  • 3,4,5-Trimethoxycinnamic acid, methyl reserpate
  • 3,4,5-Trimethoxycinnamoyl methyl reserpate
  • 3,4,5-trimethoxycinnamoylmethylreserpate
  • 3,4,5-Trimethylcinnamic acid, ester with methyl reserpate
  • 3,4,5-trimethylcinnamicacid,esterwithmethylreserpate
  • 3,4,5-Trimethylcinnamoyl methyl reserpate
  • 3,4,5-trimethylcinnamoylmethylreserpate
  • 3beta,20alpha-Yohimban-16beta-carboxylic acid, 18beta-hydroxy-11,17alpha-dimethoxy-, methyl ester, 3,4,5-trimethoxycinnamate (ester)
  • 3-beta,20-alpha-Yohimban-16-beta-carboxylic acid, 18-beta-hydroxy-11,17-alpha-dimethoxy-,methyl ester, 3,4,5-trimethoxycinnamate
  • 3beta,20alpha-yohimban-16beta-carboxylicacid,18beta-hydroxy-11,17alpha-dimeth
  • 3beta,20alpha-yohimban-16beta-carboxylicacidmethylester
  • Anapral
  • Apolon
  • Apoterin
  • Apoterin S
  • Benz(g)indolo(2,3-a)quinolizine-1-carboxylic acid, 1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-3-hydroxy-2,11-dimethoxy-, methyl ester, 3,4,5-trimethoxycinnamate
  • Cartric
  • Cinamine
  • Cinatabs
  • Cinnaloid
  • Cinnasil
  • imethoxy-,methylester,3,4,5-trimethoxycinnamate(ester)
  • Methyl 11,17-dimethoxy-18-([(2E)-3-(3,4,5-trimethoxyphenyl)-2-propenoyl]oxy)yohimban-16-carboxylate
  • Methyl 18beta-hydroxy-11,17alpha-dimethoxy-3beta,20alpha-yohimban-16beta-carboxylate
  • Methyl 18-O-(3,4,5-trimethoxycinnamoyl)reserpate
  • Methyl trimethoxycinnamoylreserpate
  • methyl18-o-(3,4,5-trimethoxycinnamoyl)reserpate
  • methyl18-o-(3,4,5-trimethoxycinnamoylreserpate
  • methylester,3,4,5-trimethoxycinnamate(ester),(e)-oxy
  • methyltrimethoxycinnamoylreserpate
  • Moderil
  • Normorescina
  • Paresinan
  • Raupyrol
  • Raurescin
  • Raurescine
  • Recinnamine
  • Recitensina
  • Rescaloid
  • Rescamin
  • Rescidan
  • Rescin
  • Rescinnamin
  • Rescinpal
  • Rescisan
  • Rescitens
  • Resealoid
  • resepinine(c35alkaloid)
  • Reserpinene
  • Reserpinin
  • Reserpinine (C35 alkaloid)
  • reserpinine[c35alkaloid]
  • Resipal