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RESCINNAMINE

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RESCINNAMINE Basic information
RESCINNAMINE Chemical Properties
  • Melting point:238-239°C
  • alpha D24 -97° (c = 1 in chloroform)
  • Boiling point:669.26°C (rough estimate)
  • Density 1.2161 (rough estimate)
  • refractive index 1.5300 (estimate)
  • storage temp. 2-8°C
  • pkapKa 6.4 (Uncertain)
  • Stability:Stable, but darkens slowly in light. Incompatible with strong oxidizing agents.
  • EPA Substance Registry SystemRescinnamine (24815-24-5)
Safety Information
  • Hazard Codes Xn
  • Risk Statements 25-20/21/22
  • Safety Statements 22-45-36
  • RIDADR 1544
  • HazardClass 6.1(b)
  • PackingGroup III
RESCINNAMINE Usage And Synthesis
  • Chemical Propertieswhite to cream powder
  • UsesRescinnamine occurs in the roots of a num ber of Rauwolfia species. Therapeutically, itis used as an antihypertensive agent.
  • brand nameModeril (Pfizer).
  • General DescriptionOdorless white to cream colored crystalline powder.
  • Air & Water ReactionsInsoluble in water.
  • Reactivity ProfileThe neat material darkens slowly on exposure to light. In solution this occurs more rapidly. .
  • Health HazardThe pharmacological properties of rescinnamine are similar to those of reserpine, butthe side effects are low. It acts as a sedativeand hypotensive. A dose of 0.25 mg/day mayproduce the effect of sleepiness in humans.Excessive doses may produce depression,nightmare, nausea, diarrhea, and hypotension.
    LD50 value, oral (rats): 1000 mg/kg
    The carcinogenicity of rescinnamine inanimals or humans is unknown.
  • Fire HazardFlash point data for RESCINNAMINE are not available. RESCINNAMINE is probably combustible.
  • Purification MethodsCrystallise it from *benzene, MeOH or aqueous Me2CO. The hydrochloride has m 232o(dec) (from MeOH) and [] D -74o (MeOH). It is an antihypertensive. [Klohs et al. J Am Chem Soc 77 2241 1955, Beilstein 25 III/IV 1323.]
RESCINNAMINE(24815-24-5)Related Product Information
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