Chemical Properties
CLEAR YELLOW TO BROWNISH LIQUID
Uses
3,3-Diethoxypropionitrile may be used in the synthesis of 2-(2,2-diethoxy-ethyl)-pyridine, via [2+2+2]-cycloaddition reaction. It may be used in the synthesis of cyanomalondialdehyde.
Uses
3,3-Diethoxypropionitrile is a propionitrile derivative used in the preparation of various biologically active compounds such as p38α mitogen-activated protein kinase inhibitors.
Synthesis Reference(s)
Journal of the American Chemical Society, 69, p. 2657, 1947
DOI: 10.1021/ja01203a028
General Description
3,3-Diethoxypropionitrile is a cyanide derivative. It undergoes reaction with urea in refluxing butanolic sodium butoxide to afford 4-amino-2(1
H)-pyrimidinone and cytosine. Its physical properties (density, refractive index, boiling point and melting point) have been reported.
