Description Source Uses structure and hydrogen bonding Application
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NOBILETIN

Description Source Uses structure and hydrogen bonding Application
NOBILETIN Structure
NOBILETIN
  • CAS No.478-01-3
  • Chemical Name:NOBILETIN
  • CBNumber:CB3740677
  • Molecular Formula:C21H22O8
  • Formula Weight:402.39
  • MOL File:478-01-3.mol
NOBILETIN Property
  • Melting point: :136.0 to 140.0 °C
  • Boiling point: :587.9±50.0 °C(Predicted)
  • Density  :1.244±0.06 g/cm3(Predicted)
  • storage temp.  :-20°C
  • form  :neat
  • BRN  :360887
  • InChIKey :MRIAQLRQZPPODS-UHFFFAOYSA-N
  • CAS DataBase Reference :478-01-3(CAS DataBase Reference)
  • EWG's Food Scores :1
  • FDA UNII :D65ILJ7WLY
Safety
  • Safety Statements  :24/25
  • WGK Germany  :3
  • RTECS  :DJ3052200
  • HS Code  :29329990
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
NOBILETIN Price More Price(8)
  • Brand: Sigma-Aldrich
  • Product number: N1538
  • Product name : Nobiletin
  • Purity: ≥97%
  • Packaging: 5mg
  • Price: $265
  • Updated: 2019/12/02
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: N1538
  • Product name : Nobiletin
  • Purity: ≥97%
  • Packaging: 10mg
  • Price: $665
  • Updated: 2019/12/02
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: N0871
  • Product name : Nobiletin
  • Purity: >95.0%(HPLC)
  • Packaging: 10mg
  • Price: $130
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: N0871
  • Product name : Nobiletin
  • Purity: >95.0%(HPLC)
  • Packaging: 100mg
  • Price: $715
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 15421
  • Product name : Nobiletin
  • Purity: ≥98%
  • Packaging: 5mg
  • Price: $35
  • Updated: 2021/03/22
  • Buy: Buy

NOBILETIN Chemical Properties,Usage,Production

  • Description Nobiletin (NOB) chemically known as 5,6,7,8,3′,4′-hexamethoxyflavone is a dietary polymethoxylated flavonoid found in Citrus fruits. Nobiletin is a flavonoid isolated from citrus peels. It is an O-methylated flavone that has the activity to rescue bulbectomy-induced memory impairment.

  • Source Nobiletin is a nonpolar polymethoxylated flavone (PMFs) found in the citrus peel of various fruits, such as tangerine. Its chemical structure is similar to tangeretin, containing the typical flavonoid structure and six methoxyl groups (one more than tangeretin).
  • Uses NOB is a multifunctional pharmaceutical agent. The various pharmacological activities of NOB include neuroprotection, cardiovascular protection, antimetabolic disorder, anticancer, anti-inflammation, and antioxidation.
  • structure and hydrogen bonding The crystal structure study on NOB shows that the chromene and the arene rings are almost in the same plane. The C atoms of the two methoxy groups in the arene ring are also in the same plane, while the C atoms of four methoxy groups linking to the chromene ring are not in parallel. This conformational characteristic of chiral structure is indicated by the covalent bond rotation between the arene and the chromene rings and the conformational alternations of methoxy groups.
  • Application Nobiletin has been shown to exhibit antioxidant, anti-inflammatory, antitumor/cancer, and antiangiogenic activity in vitro and in vivo. Animal and in vitro data also demonstrate nobiletin's potential ability to suppress bone loss, lower cholesterol and atherosclerosis, and improve hyperglycemia and insulin resistance.
  • Chemical Properties White powder
  • Uses matrix metaloproteinase inhibitor; antineoplastic
  • Definition ChEBI: A methoxyflavone that is flavone substituted by methoxy groups at positions 5, 6, 7, 8, 3' and 4' respectively.
NOBILETIN Preparation Products And Raw materials
Raw materials
Preparation Products
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478-01-3, NOBILETINRelated Search:
  • biletin
  • Nobiletin, 98%, from Citrus nobilis Lour.
  • Nobiletin, froM Citrus nobilis Lour.
  • Chuanpi glycosides
  • 4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-
  • Nobiletin, >=98%
  • NOBILETIN
  • 3',4',5,6,7,8-HEXAMETHOXYFLAVONE
  • NOBILETIN WITH HPLC
  • NOBILETIN, 20% (TECHNICAL GRADE)
  • 4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-
  • 5,6,7,8-tetramethoxy-
  • Nobiletin,Hexamethoxyflavone
  • 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one
  • 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-chromen-4-one
  • 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one
  • 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-chromone
  • Flavone, 5,6,7,8,3',4'-hexamethoxy
  • hexamethoxyflavone
  • Nobiletin 478-01-3
  • Nobiletin&gt
  • Nobiletin (100 mg) (2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-chromen-4-one)
  • 478-01-3
  • C21H22O8
  • chemical reagent
  • pharmaceutical intermediate
  • CITRIMORE
  • Inhibitors
  • natural product
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Hexa-substituted Flavones