Supplier Related Products Identification Questions And Answer Chemical Properties Safety Data
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478-01-3

Supplier Related Products Identification Questions And Answer Chemical Properties Safety Data

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Identification

Name
NOBILETIN
CAS
478-01-3
Synonyms
3',4',5,6,7,8-HEXAMETHOXYFLAVONE
NOBILETIN
Flavone, 5,6,7,8,3',4'-hexamethoxy
hexamethoxyflavone
NOBILETIN WITH HPLC
NOBILETIN, 20% (TECHNICAL GRADE)
4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-
5,6,7,8-tetramethoxy-
Nobiletin,Hexamethoxyflavone
2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one
Molecular Formula
C21H22O8
MDL Number
MFCD03273560
Molecular Weight
402.39
MOL File
478-01-3.mol

Questions And Answer

Description
Nobiletin (NOB) chemically known as 5,6,7,8,3′,4′-hexamethoxyflavone is a dietary polymethoxylated flavonoid found in Citrus fruits. Nobiletin is a flavonoid isolated from citrus peels. It is an O-methylated flavone that has the activity to rescue bulbectomy-induced memory impairment.


Source
Nobiletin is a nonpolar polymethoxylated flavone (PMFs) found in the citrus peel of various fruits, such as tangerine. Its chemical structure is similar to tangeretin, containing the typical flavonoid structure and six methoxyl groups (one more than tangeretin).
Uses
NOB is a multifunctional pharmaceutical agent. The various pharmacological activities of NOB include neuroprotection, cardiovascular protection, antimetabolic disorder, anticancer, anti-inflammation, and antioxidation.
structure and hydrogen bonding
The crystal structure study on NOB shows that the chromene and the arene rings are almost in the same plane. The C atoms of the two methoxy groups in the arene ring are also in the same plane, while the C atoms of four methoxy groups linking to the chromene ring are not in parallel. This conformational characteristic of chiral structure is indicated by the covalent bond rotation between the arene and the chromene rings and the conformational alternations of methoxy groups.
Application
Nobiletin has been shown to exhibit antioxidant, anti-inflammatory, antitumor/cancer, and antiangiogenic activity in vitro and in vivo. Animal and in vitro data also demonstrate nobiletin's potential ability to suppress bone loss, lower cholesterol and atherosclerosis, and improve hyperglycemia and insulin resistance.

Chemical Properties

CAS DataBase Reference
478-01-3(CAS DataBase Reference)

Safety Data

HS Code 
29329990
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