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Lincomycin

Lincomycin  Structure
Lincomycin
  • CAS No.154-21-2
  • Chemical Name:Lincomycin
  • CBNumber:CB3492619
  • Molecular Formula:C18H34N2O6S
  • Formula Weight:406.54
  • MOL File:154-21-2.mol
Lincomycin Property
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
Lincomycin Price More Price(2)
  • Brand: Cayman Chemical
  • Product number: 21526
  • Product name : Lincomycin
  • Purity: ≥98%
  • Packaging: 5mg
  • Price: $105
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 21526
  • Product name : Lincomycin
  • Purity: ≥98%
  • Packaging: 25mg
  • Price: $394
  • Updated: 2021/03/22
  • Buy: Buy

Lincomycin Chemical Properties,Usage,Production

  • Description Lincomycin is an antibiotic active against grampositive bacteria. Occupational exposure occurs in poultry and pig breeders.
  • Chemical Properties White Crystalline Solid
  • Originator Lincocin,Upjohn,UK,1964
  • Uses An antibiotic produced by Streptomyces lincolnensis. Antibacterial
  • Uses Lincomycin is a polar, water soluble, broad spectrum antibiotic first isolated from Streptomyces licolnensis by researchers at Upjohn in 1962. Lincomycin was the first of a unique structural class, the lincosamides, containing a rare amino acid, 4-propyl-N-methylproline, coupled to an equally rare aminomethylthio-octopyranoside sugar. Lincomycin and semi-synthetic analogues are often incorrectly considered to be aminoglycosides but share little or no structural similarity. Lincomycin is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Lincomycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Lincomycin has been extensively studied with over 7,000 literature citations.
  • Definition ChEBI: A carbohydrate-containing antibiotic produced by the actinomyces Streptomyces lincolnensis.
  • Manufacturing Process As described in US Patent 3,086,912, the process comprises cultivating Streptomyces lincolnensis var. lincolnensis in an aqueous nutrient medium containing a source of assimilable carbohydrate and assimilable nitrogen under aerobic conditions until substantial activity is imparted to the medium by production of lincolnensin and isolating the lincolnensin so produced.
  • brand name Lincocin (Pharmacia & Upjohn).
  • Therapeutic Function Antibacterial
  • Antimicrobial activity Lincomycin has an antibacterial effect with respect to Gram-positive microorganisms (staphylococci, streptococci, pneumococci, diphtheria bacillus, and clostridia). It is used for serious bacterial infections: sepsis, osteomyelitis, septic endocarditis, pneumonia, pulmonary abscess, infected wounds, and purulent meningitis. Lincomycin is a reserve drug for infections caused by strains of staphylococci and other Gram-positive microorganisms that are resistant to penicillin and other antibiotics. Synonyms of this drug are lincocin, mycivin, albiotic, and others.
  • Contact allergens Lincomycin is an antibiotic of the lincosanide group,active against Gram-positive bacteria. Occupational exposure occurs in poultry and pig breeders
  • Clinical Use Lincomycin is a natural product isolated from fermentations of Streptomyces lincolnensisvar. lincolnensis. It is active against Gram-positive organisms, including some anaerobes. It is indicated for the treatment of serious infections caused by sensitive strains of streptococci, pneumococci, and staphylococci. It generally is reserved for patients who are allergic to penicillin because of the increased risk of pseudomembranous colitis. It also serves as the starting material for the synthesis of clindamycin (by a SN-2 reaction that inverts the R stereochemistry of the C-7 hydroxyl to a C-7 S-chloride).
  • Chemical Synthesis Lincomycin, 6,8-dideoxy-6-trans-(1-methyl-4-propyl-L-2-pyrrolidincarboxamido)-1-methylthio-D-erythro-α-D-galacto-octopyranoside (32.5.1), is the first lincosamide that has found use in clinical practice, and which was isolated in 1962 from the culture liquid of the activity of the actinomycete Streptomyces lincolnensis.
  • Veterinary Drugs and Treatments Lincomycin has dosage forms approved for use in dogs, cats, swine, and in combination with other agents for chickens. Because clindamycin is generally better absorbed, more active, and probably less toxic, it has largely supplanted the use of lincomycin for oral and injectable therapy in small animals, but some clinicians believe that clindamycin does not offer enough clinically significant improvements over lincomycin to justify its higher cost. For further information, refer to the Pharmacology or Doses sections.
Lincomycin Preparation Products And Raw materials
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154-21-2, Lincomycin Related Search:
  • U-10149A
  • LINCOMYCIN STANDARD
  • LINCOMYCIN
  • LYNCOMYCIN
  • Lincomycin HCL Bp98 USP24 EPIII CP2000
  • Lincomycin hydrochoride
  • Lincomycin(baseand/orunspecifiedsalt)
  • Albiotic
  • Cillimycin
  • D-erythro-alpha-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, (2S-trans)-
  • methyl6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecarboxamido)-1-thio-d-eryt
  • NSC-70731
  • trans-alpha
  • trans-alpha-opyl-2-pyrrolidinyl)carbonyl)amino)-1-thio
  • trans-alpha--pyrrolidinecarboxamido)-1-thio
  • U-10149
  • (2S-trans)-Methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-D-threo-a-D-galacto-octopyranoside
  • D-erythro-a-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, (2S-trans)-
  • D-erythro-a-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio- (9CI)
  • D-erythro-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-, trans-a- (8CI)
  • Lincomycin (base and/or unspecified salts)
  • Clindamycin Phosphate EP Impurity A (Clindamycin HCl EP Impurity A)
  • Clindamycin Phosphate EP Impurit A
  • methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propylpyrrolidin-2yl]carbonyl]amino]-1-thio-D-erythro-α-D-galacto-octopyranoside
  • Clindamycin Impurity 10(Clindamycin Phosphate)
  • Clindamycin HCl EP Impurity A )
  • Clindamycin Phosphate EP Impurity A/Lincomycin/(2S,4R)-N-((1R,2R)-2-hydroxy-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)propyl)-1-methyl-4-propylpyrrolidine-2-carboxamide
  • Methyl 6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecarboxamido)-1-thio-D-erythro-a-D-galactooctopyranoside hydrochloride
  • Methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-D-erythro-alpha-D-gluco-octopyranoside
  • (2S-trans)-Methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-D-threo-α-D-galacto-octopyranoside Hydrochloride
  • (2S-trans)-Methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-D-threo-a-D-galacto-octopyranoside Hydrochloride
  • d-erythro-alpha-d-galacto-octopyranoside,methyl6,8-dideoxy-6-(((1-methyl-4-pr
  • D-erythro-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-, trans- alpha-
  • d-erythro-d-galacto-octopyranoside,methyl-6,8-dideoxy-6-(1-methyl-4-propyl-l-2
  • d-erythro-d-galacto-octopyranoside,methyl6,8-dideoxy-6-(1-methyl-4-propyl-l-2
  • hro-d-galacto-octopyranoside(alpha-form)
  • jiemycin
  • Lincocine
  • Lincolcina
  • Lincolnensin
  • lincomycina
  • Lincomycine
  • Lincomyocin
  • Methyl 6,8-dideoxy-6-([(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino)-1-thiooctopyranoside
  • Methyl 6,8-dideoxy-6-trans-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-D-erythro-alpha-D-galacto-octopyranoside
  • (2S,4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3S,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyl-oxan-2-yl]propyl]-1-methyl-4-propyl-pyrrolidine-2-carboxamide
  • Methyl-D-erythro-a-D-galacto-octopyranoside
  • Myvicin
  • Linocin, Lincolnensin, U 10149, JieMycin
  • Clindamycin EP Impurity A
  • Clindamycin Phosphate EP Impurity A
  • Clindamycin Phosphate EP Impurities
  • Clindamycin Impurity 10(Clindamycin Phosphate EP Impurity A
  • (2S-trans)-Methyl 6,8-Dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl ]amino]-1-thio-D-erythro-α-D-galacto-octopyranoside
  • D-erythro-α-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-
  • Clindamycin EP Impurity A (Lincomycine)
  • Lincomycin USP/EP/BP
  • Clindamycin Impurity 10(Clindamycin Phosphate EP Impurity A,Clindamycin HCl EP Impurity A )