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Sugammadex sodium

Sugammadex sodium Structure
Sugammadex sodium
  • CAS No.343306-79-6
  • Chemical Name:Sugammadex sodium
  • CBNumber:CB32502868
  • Molecular Formula:C72H104Na8O48S8
  • Formula Weight:2177.97
  • MOL File:343306-79-6.mol
Sugammadex sodium Property
  • storage temp.  :Inert atmosphere,Room Temperature
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
Sugammadex sodium Price More Price(3)
  • Brand: Cayman Chemical
  • Product number: 24096
  • Product name : Sugammadex (sodium salt)
  • Purity: ≥98%
  • Packaging: 1mg
  • Price: $25
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 24096
  • Product name : Sugammadex (sodium salt)
  • Purity: ≥98%
  • Packaging: 5mg
  • Price: $113
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 24096
  • Product name : Sugammadex (sodium salt)
  • Purity: ≥98%
  • Packaging: 10mg
  • Price: $200
  • Updated: 2021/03/22
  • Buy: Buy

Sugammadex sodium Chemical Properties,Usage,Production

  • Description To facilitate tracheal intubation, mechanical ventilation, and surgical access, NMB agents are frequently used as non-anesthetic adjuncts in surgical procedures. Sugammadex is able to function as a pharmacologic sink of rocuronium and vecuronium, another non-depolarizing neuromuscular blocker, without the cardiovascular adverse effects experienced with reversal agents that directly interact with the cholinergic system. The γ-cyclodextrin has been designed to enhance binding of the guest by incorporating acidic side chains to promote an electrostatic interaction with the positive nitrogen of the blocker. Starting with γ-cyclodextrin, these side chains are readily installed by first halogenating with iodine or bromine to provide a handle for nucleophilic displacement with either 3-mercaptopropionic acid in the presence of sodium hydride or with 3-mercaptopropionic acid methyl ester and cesium carbonate. The latter requires hydrolysis with sodium hydroxide to generate sugammadex sodium.
  • Chemical Properties Colorless, orthorhombic crystals from DMF + water. d 1.446. Solubility in water.
  • Originator Organon (Netherlands)
  • Uses Reversal agent for neuromuscular blocking drugs.
  • Definition ChEBI: An organic sodium salt that is the octasodium salt of sugammadex. Used for reversal of neuromuscular blockade induced by rocuronium and vecuronium in adults undergoing surgery.
  • brand name Bridion
  • Side effects The most common adverse effects included coughing, movement, vomiting, dry mouth, dysgeusia, hypotension, parosmia, and a sensation of changed temperature.Sugammadex is recommended for the reversal of neuromuscular blockade induced by rocuronium or vecuronium; it should not be used with other steroidal blocking agents since safety and efficacy data are not available for these situations. It should also not be partnered with non-steroidal neuromuscular blockers such as succinylcholine or benzylisoquinolinium-based drugs. Since sugammadex is predominantly cleared by the kidneys, care should be taken when administering this reversal agent in patients with renal impairment.
Sugammadex sodium Preparation Products And Raw materials
Raw materials
Preparation Products
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  • C72H104Na8O48S8
  • C72H104O48S88Na
  • API