Supplier Related Products Identification Chemical Properties Hazard Information
WebSite >  CAS DataBase List  > 343306-79-6

343306-79-6

Supplier Related Products Identification Chemical Properties Hazard Information

Product Image

Identification

Name
Sugammadex sodium
CAS
343306-79-6
Synonyms
ORG
CS-2749
Sugammadex Na
Sugammadex IMP
Glucose-sodium
Sugammadex Sudium
Sugammadex sodico
Sugammdaex sodium
Sugammadex soidum
ORG-25969/SugaMMadex
Sugammadex sodium-001
Sulgeng glucose sodium
Sugammadex Sodium salt
Sugammadex Sodium Sodium
Sugammadex sodium iMpurity
Sugammadex Octasodium Salt
Sugammadex sodium USP/EP/BP
Sugammadex soidum 343306-79-6
Sugammadex sodium CAS 343306 79 6
Sugammadex Sodium intermediate II
6A,6B,6C,6D,6E,6F,6G,6H-octakis-S-(2-Carboxyethyl)-6A,6B,6C,6D,6E,6F,6G,6H-octathio-γ-cyclodextrin Sodium Salt
6A,6B,6C,6D,6E,6F,6G,6H-Octakis-S-(2-carboxyethyl)-6A,6B,6C,6D,6E,6F,6G-octasulfanyl-gamma-cyclodextrin octasodium salt
Molecular Formula
C72H104Na8O48S8
MOL File
343306-79-6.mol
Molecular Weight
2177.97

Chemical Properties

storage temp. 
Inert atmosphere,Room Temperature
CAS DataBase Reference
343306-79-6

Hazard Information

Description
To facilitate tracheal intubation, mechanical ventilation, and surgical access, NMB agents are frequently used as non-anesthetic adjuncts in surgical procedures. Sugammadex is able to function as a pharmacologic sink of rocuronium and vecuronium, another non-depolarizing neuromuscular blocker, without the cardiovascular adverse effects experienced with reversal agents that directly interact with the cholinergic system. The γ-cyclodextrin has been designed to enhance binding of the guest by incorporating acidic side chains to promote an electrostatic interaction with the positive nitrogen of the blocker. Starting with γ-cyclodextrin, these side chains are readily installed by first halogenating with iodine or bromine to provide a handle for nucleophilic displacement with either 3-mercaptopropionic acid in the presence of sodium hydride or with 3-mercaptopropionic acid methyl ester and cesium carbonate. The latter requires hydrolysis with sodium hydroxide to generate sugammadex sodium.
Chemical Properties
Colorless, orthorhombic crystals from DMF + water. d 1.446. Solubility in water.
Originator
Organon (Netherlands)
Uses
Reversal agent for neuromuscular blocking drugs.
Definition
ChEBI: An organic sodium salt that is the octasodium salt of sugammadex. Used for reversal of neuromuscular blockade induced by rocuronium and vecuronium in adults undergoing surgery.
Brand name
Bridion
Side effects
The most common adverse effects included coughing, movement, vomiting, dry mouth, dysgeusia, hypotension, parosmia, and a sensation of changed temperature.Sugammadex is recommended for the reversal of neuromuscular blockade induced by rocuronium or vecuronium; it should not be used with other steroidal blocking agents since safety and efficacy data are not available for these situations. It should also not be partnered with non-steroidal neuromuscular blockers such as succinylcholine or benzylisoquinolinium-based drugs. Since sugammadex is predominantly cleared by the kidneys, care should be taken when administering this reversal agent in patients with renal impairment.
SupplierMore