Synthesis
The general procedure for the synthesis of N,N'-bis(2-hydroxyethyl)piperazine from diethanolamine is as follows:
Example 2: Preparation of 1,4-bis(hydroxyethyl)piperazine from diethanolamine under solvent-free conditions
Operational steps:
1. 100 g of diethanolamine (II) and 10 g of Catalyst A were added in the same reaction setup described in Example 1 .
2. Upon completion of the reaction, the reaction product was detected by gas chromatography analysis (GC column: 30m RTX Amin).
3. The analytical results showed that the content of 1,4-bis(hydroxyethyl)piperazine in the reaction product was 79% under the condition of complete conversion of diethanolamine.
References
[1] Patent: US2012/108816, 2012, A1. Location in patent: Page/Page column 6
[2] Patent: US2868791, 1954,
[3] Patent: US2636033, 1950,
[4] Patent: DE917784, 1952,