Chemical Properties
White or almost white powder.
Uses
Antibacterial (topical).
Uses
Mupirocin (M794000), is a major component of the pseudomonic acid, an antibiotic complex produced by Pseudomonas fluorescens NCIB 10586. Topical antibacterial.
Definition
ChEBI: Mupirocin calcium hydrate is a hydrate that is the dihydrate form of mupirocin calcium. It is an antibacterial drug used for the treatment of skin infections such as impetigo caused by Staphylococcus aureus and meticillin-resistant Staphylococcus aureus (MRSA). It has a role as an antibacterial drug, a protein synthesis inhibitor and an antiinfective agent. It contains a mupirocin calcium (anhydrous).
brand name
Bactroban (GlaxoSmithKline).
in vivo
MRSA: Meticillin-resistant Staphylococcus aureus
Mupirocin (BRL-4910A, Pseudomonic acid) calcium is well absorbed after oral and parenteral administration but serum antibiotic concentrations were short-lived as a result of extensive degradation to the antibacterially inactive metabolite, monic acid A[1].
Mupirocin calcium (2% ointment; external administration; twice daily; 3-6 d) decreases the total bacterial loads in the skin lesions with either topical treatment[3].
Mupirocin calcium (2% ointment; external administration; 4 d) alleviates MRSA-infected pressure ulcers in mice[4].
Mupirocin calcium (100 mg/mL; s.c.; 7 d) exerts prevention efficacy against vascular prosthetic graft infection due to Staphylococcus epidermidis[5].
| Animal Model: | MRSA skin infection model in mice (10-12 weeks old)[3] |
| Dosage: | 2% ointment |
| Administration: | External administration; twice daily; 3-6 days |
| Result: | Reduced the total bacterial loads in the skin lesions, and decreased by 2.0, 5.1 log10 CFU on day 3 and 6, respectively.
|
| Animal Model: | Diabetic pressure ulcer mouse model (33.2-39.2 g)[4] |
| Dosage: | 2% ointment |
| Administration: | External administration; 4 days |
| Result: | Resulted less superficial mats of bacterial colonies, and improved histopathology evaluation.
|
| Animal Model: | Adult male Wistar rats (weight 275-325 g)[5] |
| Dosage: | Impregnated with 100 μg of mupirocin/mL; segments:1.5 cm *1 cm2 |
| Administration: | Subcutaneous implantation; 7 days |
| Result: | Resulted in preventing S. epidermidis infection of the graft in a rat model with spontaneously bound to collagen-sealed Dacron grafts.
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