Polymyxin B
- Product NamePolymyxin B
- CAS1404-26-8
- CBNumberCB4902083
- MFC55H96N16O13
- MW0
- EINECS215-768-4
- MDL NumberMFCD01775374
- MOL FileMol file
- MSDS FileSDS
Polymyxin B Chemical Properties,Usage,Production
Description
Polymyxin B was isolated by Wellcome Research Laboratories, in 1949, from the mixture of polymyxins A, B, C, and D produced byBacillus polymyxa. It was later separated into the major component, B1, and the minor component, B2. Polymyxin B is a basic polypeptide and shows strong activity against gram-negative bacteria, but its activity against gram-positive bacteria, Mycobacterium, and fungi is weak. Because of its toxicity, it is used carefully by intramuscular injection for resistant Pseudomonas aeruginosa infections, e.g., sepsis. Polymyxin B is used orally to sterilize the gut in leukemic patients, intraspinally for meningitis, or topically.Uses
Antibacterial Aerosporin.Definition
ChEBI: A polymyxin having a 6-methylheptanoyl group at the amino terminus.brand name
(GlaxoSmithKline); Poly-Rx (X Gen).Contact allergens
Active against Gram-negative bacteria, Polymyxin B is a mixture of Polymyxin B1 and B2. Sensitization occurs by topical, ophthalmic, and otic preparations. Cosensitization is frequent with other topical antibiotics like neomycin or bacitracin.Preparation Products And Raw materials
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