Chemical Properties
white to light yellow crystal powder
Uses
2-Aminopurine has been used to inhibit eukaryotic initiation factor-2α (eIF2α)-phosphorylation of osteoarthritis (OA) chondrocytes.
Uses
A probe of structural dynamics and charge transfer in DNA .
Uses
A probe of structural dynamicas and charge transfer in DNA
Definition
ChEBI: The parent compound of the 2-aminopurines, comprising a purine core carrying an amino substituent at the 2-position.
Biochem/physiol Actions
2-Aminopurine (2AP) is an analog of guanosine and adenosine, which can base pair with cytosine and thymine. It is used as a fluorescent probe in nucleic acid structure and dynamics. 2-Aminopurine (2-AP) inhibits double-stranded RNA-dependent protein kinase, protein kinase R (PKR).
Safety Profile
Mutation data reported. Whenheated to decomposition it emits toxic fumes of NOx.
