1. Materials information
Names
Name | 2-aminopurine |
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Synonym | More Synonyms |
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2-Aminopurine Biological Activity
Description | 2-Aminopurine, a fluorescent analog of guanosine and adenosine, is a widely used fluorescence-decay-based probe of DNA structure. When 2-Aminopurine is inserted in anoligonucleotide, its fluorescence is highly quenched by stacking with the natural bases. 2-Aminopurine has been used to probe nucleic acid structure and dynamics[1][2]. |
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Related Catalog | Research Areas >> Others Signaling Pathways >> Others >> Others |
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In Vitro | 2-Aminopurine (2AP) is not valuable as afluorescent label because its fluorescence is highly quenched by stacking with the natural bases, when it is inserted in anoligonucleotide. However, it is this very susceptibility to interbase quenching that makes 2AP an exquisitely sensitivefluorescent probe of nucleic acid structure[1]. 2-Aminopurine differs from adenine (6-aminopurine) only in the position of the exocyclic amine group, and yet its fluorescence intensity is one thousand times that of adenine[1]. |
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References | [1]. J M Jean, et al. 2-Aminopurine fluorescence quenching and lifetimes: role of base stacking. Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):37-41. [2]. Dehong Tan, et al. Decreased glycation and structural protection properties of γ-glutamyl-S-allyl-cysteine peptide isolated from fresh garlic scales (Allium sativum L.). Nat Prod Res. 2015;29(23):2219-22. |
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Chemical & Physical Properties
Density | 1.9±0.1 g/cm3 |
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Boiling Point | 328.2±25.0 °C at 760 mmHg |
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Melting Point | 280-282 °C(lit.) |
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Molecular Formula | C5H5N5 |
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Molecular Weight | 135.127 |
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Flash Point | 152.3±23.2 °C |
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Exact Mass | 135.054489 |
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PSA | 80.48000 |
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LogP | -1.33 |
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Vapour Pressure | 0.0±0.7 mmHg at 25°C |
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Index of Refraction | 1.954 |
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MSDS
2-Aminopurine MSDS(Chinese) |
Toxicological Information
CHEMICAL IDENTIFICATIONCHEMICAL NAME : Purine, 2-amino-
CAS REGISTRY NUMBER : 452-06-2
MOLECULAR FORMULA : C5-H5-N5
HEALTH HAZARD DATAACUTE TOXICITY DATASPECIES OBSERVED : Rodent - rat
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
TYPE OF TEST : Specific locus test
MUTATION DATATEST SYSTEM : Rodent - hamster Embryo
REFERENCE : PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 78,5685,1981
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Safety Information
Symbol | GHS07 |
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Signal Word | Warning |
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Hazard Statements | H302 |
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Precautionary Statements | P301 + P312 + P330 |
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Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
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Hazard Codes | Xn:Harmful; |
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Risk Phrases | R22 |
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Safety Phrases | S22-S36 |
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RIDADR | NONH for all modes of transport |
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WGK Germany | 3 |
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RTECS | UO7475000 |
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HS Code | 2933990090 |
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2. Packaging of materials
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping & Delivery
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Suitable for goods under 50kg
Delivery: 3-7 days
Cost: low cost
Provide airport to airport service
Suitable for goods over 50kg
Delivery: 3-14 days
Cost: high cost
Provide seaport to seaport service
Suitable for goods over 100kg
Delivery: 2-45 days
Cost: low cost
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