Chemical Properties
Homoplantaginin belong to flavonoids, easily soluble in methanol and ethanol, slightly soluble in acetone, and insoluble in water. Its hemihydrate is a yellow crystal.
Uses
Homoplantaginin has bacteriostatic effect. It has moderate inhibitory effect on the common pathogenic bacteria of chronic bronchitis such as Staphylococcus albus and pneumococcus in vitro. It has a certain antagonistic effect on the infection of Staphylococcus aureus in animals, and can reduce the mortality rate 20 %. It has certain antitussive and expectorant effects, and its expectorant ability is greater than that of ammonium chloride. It can be used to treat chronic bronchitis with less toxicity.
Definition
ChEBI: Homoplantaginin is a glycoside and a member of flavonoids.
Biological Activity
Homoplantaginin is and anti-inflammatory and antioxidant flavonoid isolated from medical herb Salvia plebeian (Sage weed) th at improves hepatic injury, hyperlipidemia, and hyperglycemia. Homoplantaginin ameliorates endothelial insulin resistance by inhibiting inflammation and modulating cell signalling via the IKKβ/IRS-1/pAkt/peNOS pathway. Homoplantaginin protects endothelial cells from Palmitic acid -induced inflammation by suppression of TLR4 expression, and NLRP3 inflammasome activation.
Synthesis
Extraction process of Homoplantaginin in lychee grass: lychee grass decoction pieces--crushing--solvent extraction--filtration and decompression concentration--extraction--dehydration--suction filtration silica gel column separation--purification (recrystallization)--suction filtration-- dry.
