Description
Suprofen is an arylpropionic acid analgesic/antiinflammatory agent with close
structural resemblance to ketoprofen. It is more potent in many assays than
indomethacin and ketoprofen and appears better tolerated.
Chemical Properties
Off-White to Light-Brown
Originator
Janssen (Belgium)
Uses
Prostaglandin biosynthesis inhibitor. Analgesic
Uses
Bridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist. Antiemetic.
Definition
ChEBI: An aromatic ketone that is thiophene substituted at C-2 by a 4-(1-carboxyethyl)benzoyl group.
brand name
Profenal (Alcon);Algiamida;Algiasdi;Bordol;Erdol;Masterfen;Sufenid;Supranol;Surfex;MALDOCIL.
Veterinary Drugs and Treatments
Suprofen is a non-steroidal anti-inflammatory agent similar to
flurbiprofen. Suprofen and flurbiprofen are phenylalkanoic acids
that inhibit the cyclo-oxygenase enzymes responsible for conversion
of arachadonic acid from cell membranes into various prostaglandins.
These prostaglandins mediate certain aspects of ocular
inflammation including disruption of the blood-aqueous barrier,
uveal vasodilation, increases in intraocular pressure, and leakage of
white blood cells and protein from uveal vessels into the aqueous
humor. Prostaglandins cause iris sphincter constriction (miosis)
independent of cholinergic mechanisms. Suprofen can inhibit this
intraocular miosis and may also be useful in the management of
uveal inflammation (usually in addition to topical steroids).
