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ChemicalBook Product Catalog API Antipyretic analgesics Nonsteroidal Anti-Inflammatory Drugs (NSAIDS) Suprofen

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Suprofen NEW

$35.00 5mg

$59.00 10mg

$113.00 25mg

Min. Order
Purity99.17%
Cas No40828-46-4
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	Suprofen
CAS No	40828-46-4
EC-No
Min. Order
Purity	99.17%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	Suprofen
Description	Suprofen (Suprol) is an IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic.
In vitro	Suprofen inactivates the diclofenac-4-hydroxylase activity of baculovirus-expressed P450 2C9 in a time- and concentration-dependent manner, which is consistent with mechanism-based inactivation. [1] Suprofen is a known generator of singlet oxygen whose participation in the reaction is supported by the effects of quenchers and scavengers. Suprofen photosensitizes the production of alkali-labile cleavage sites in DNA much more efficiently than direct strand breaks. [2] Suprofen sensitizes photo-oxidation of cholesterol, producing 7 alpha- and 7 beta-hydroperoxides but not 5 alpha-hydroperoxide of cholesterol. Suprofen-sensitized photo-oxidation of membrane lipids of liposomes increases leakage of trapped glucose, suggesting photosensitized destabilization of the membrane structure. [3] Suprofen incorporation in the phosphatidylcholine (PC) evaporation vesicles (REV) membrane leads to approximately 5% increase in the encapsulation efficiency (34%) in comparison to standard REV (29%). [4]
In vivo	Suprofen combined with PGF2 alpha blocks induction of uterine contractions, suggesting the possibility that Suprofen also antagonizes PGF2 alpha receptor binding. [5] Suprofen are effective at preventing BAB disruption after paracentesis in dogs, indicating their potential usefulness for treatment of prostaglandin-mediated ocular disease. [6] Suprofen (3.7 mg/kg, i.v.) induces a marked decrease in the firing evoked in arthritic rats by ankle mobilization. [7]
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 50 mg/mL (192.08 mM)
Keywords	inhibit \| TN 762 \| Suprofen \| TN762 \| Prostaglandin E synthase \| PGE synthase \| Inhibitor
Inhibitors Related	Ibuprofen \| Acetaminophen \| Salicylamide \| Diclofenac sodium \| Diclofenac Potassium \| Paradol \| Indomethacin sodium hydrate \| Trometamol \| Glafenine \| Revaprazan hydrochloride
Related Compound Libraries	Bioactive Compound Library \| Anti-Neurodegenerative Disease Compound Library \| Pain-Related Compound Library \| Drug Repurposing Compound Library \| Inhibitor Library \| FDA-Approved Drug Library \| Anti-Cancer Approved Drug Library \| Anti-Aging Compound Library \| Bioactive Compounds Library Max \| Anti-Cancer Drug Library

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