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Suprofen

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Suprofen Basic information
Suprofen Chemical Properties
  • Melting point:278°C
  • Boiling point:373.57°C (rough estimate)
  • Density 1.2959 (rough estimate)
  • refractive index 1.5050 (estimate)
  • storage temp. -20°C Freezer
  • pka3.91(at 25℃)
  • Water Solubility soluble
  • CAS DataBase Reference40828-46-4(CAS DataBase Reference)
Safety Information
  • RIDADR 3249
  • HazardClass 6.1(b)
  • PackingGroup III
  • HS Code 2934990002
  • ToxicityLD50 (7 days post-drug) in mice, rats, guinea pigs, dogs (mg/kg): 590, 353, 280, 160 orally (Niemegeers)
MSDS
Suprofen Usage And Synthesis
  • DescriptionSuprofen is an arylpropionic acid analgesic/antiinflammatory agent with close structural resemblance to ketoprofen. It is more potent in many assays than indomethacin and ketoprofen and appears better tolerated.
  • Chemical PropertiesOff-White to Light-Brown
  • OriginatorJanssen (Belgium)
  • UsesProstaglandin biosynthesis inhibitor. Analgesic
  • UsesBridged pseudopelletierine derivative; specific serotonin (5HT3) receptor antagonist. Antiemetic.
  • DefinitionChEBI: An aromatic ketone that is thiophene substituted at C-2 by a 4-(1-carboxyethyl)benzoyl group.
  • brand nameProfenal (Alcon);Algiamida;Algiasdi;Bordol;Erdol;Masterfen;Sufenid;Supranol;Surfex;MALDOCIL.
  • Veterinary Drugs and TreatmentsSuprofen is a non-steroidal anti-inflammatory agent similar to flurbiprofen. Suprofen and flurbiprofen are phenylalkanoic acids that inhibit the cyclo-oxygenase enzymes responsible for conversion of arachadonic acid from cell membranes into various prostaglandins. These prostaglandins mediate certain aspects of ocular inflammation including disruption of the blood-aqueous barrier, uveal vasodilation, increases in intraocular pressure, and leakage of white blood cells and protein from uveal vessels into the aqueous humor. Prostaglandins cause iris sphincter constriction (miosis) independent of cholinergic mechanisms. Suprofen can inhibit this intraocular miosis and may also be useful in the management of uveal inflammation (usually in addition to topical steroids).
Suprofen Preparation Products And Raw materials
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