Chemical Properties
Clear colorless to light yellow liquid
Uses
Ethyl 2-fluoropropionate is used as a solvent for lithium secondary batteries. Ethyl-2-fluoropropionate is also used as a reagent to synthesize a series of potent Nicotinic Acid (N429250) receptor agonists for the treatment of dyslipidemia, a health condition characterized by high triglyceride levels.
Synthesis Reference(s)
The Journal of Organic Chemistry, 55, p. 2311, 1990
DOI: 10.1021/jo00295a016
Synthesis
In a 2L four-neck flask equipped with a condenser, 1100 g of DMF, 273 g (2.0 mol) of ethyl 2-chloropropionate, 54 g of tetrabutylammonium bromide, 5.5 g of triethyl orthoformate and 255.2 g of potassium fluoride were added. The mixture was stirred and warmed to 100°C and reacted for 12 hours. After completion of the reaction, the mixture was purified by distillation to give 176.3 g of ethyl 2-fluoropropionate with 99.5% purity and 66.5% yield.
References
[1] Patent: CN105037150, 2017, B. Location in patent: Paragraph 0028; 0029
