Synthesis
Work on halogenated benzenes has also demonstrated the versatility of this technique and a variety of fluoro-chloro and -bromo benzenes may be de-brominated and de-chlorinated. Two patents describe removal of chlorine from 2,6-dichloro-3,5- difluoronitrobenzene giving 3,5-difluoroaniline.
Chemical Properties
white to yellowish low melting solid
Uses
3,5-Difluoroaniline has been used in the preparation of 3,5-difluorodimethylaniline.
Application
3,5-Difluoroaniline is mainly used as a key intermediate in the synthesis of complex organic molecules such as pharmaceuticals (e.g., antibacterial drugs, anti-inflammatory drugs), pesticides (e.g., herbicides), and dyes.
General Description
In vitro nephrotoxic effects of 3,5-difluoroaniline has been investigated in renal cortical slices obtained from the kidneys of untreated, male Fischer 344 rats.
References
[1] Patent: CN108314624, 2018, A. Location in patent: Paragraph 0054; 0055; 0056; 0057
