Sulfamethazine (80 mg/kg; intravenous injection; healthy female pigs) treatment significantly reduces α, β and AUC0->∞, significantly increases t1/2α, Vd and CIB, and upon a single intramuscular administration of 80 mg/kg of Sulfamethazine the absolute bioavailability in pigs is 1.01[1].
| Animal Model: | 19 healthy female pigs (6-week-old, 4.5-6.2 kg)[1] |
| Dosage: | 80 mg/kg |
| Administration: | Intravenous injection (Pharmacokinetic study) |
| Result: | The half-life in distribution phase is 0.23 h and half-lifes in eliminations phase is 9.8 h. α, β and the AUC0->∞ were significantly decreased and t1/2α, Vd and CIB were significantly increased, and the absolute bioavailability in pigs is 1.01.
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