Description
Moenomycin complex is a mixture of moenomycins A, A
12, C
1, C
3 and C
4, which are antibiotics isolated from several strains of
Streptomyces that directly inhibit bacterial peptidoglycan glycosyltransferases. The minimal inhibitory concentration of moenomycin A against various Gram-
positive bacteria ranges from 1-
100 nM.
Uses
Moenomycin complex is a mixture of five major components, A, A12, C1, C3 and C4, isolated from several strains of Streptomyces in the 1960s. Moenomycins are high molecular weight phosphoglycolipids with potent antibiotic activity used in animal health. Moenomycins are the only antibiotic known to selectively inhibit the transglycosylation step catalysed by penicillin-binding protein 1b.
Uses
Moenomycin complex is an antibiotic and selective inhibitor of the transglycosylation step. Flavomycin (bambermycins) is an antibiotic complex obtained from Streptomyces bambergiensis containing mainly Moenomycins A and C. They are used as feed additives and growth promoters for swine, poultry and cattle.
Definition
ChEBI: A glycophospholipid antibiotic compound with the lipid portion conjugated to a pentasaccharide fraction via a phosphate linkage.
brand name
Flavomycin (Hoechst-Roussel).
General Description
Flavophospholipol, formerly called moenomycin, was found in the culture broth of Streptomyces bambergiensis by Hoechst in 1955. This drug is called bambermycin by INN and in the United States. It shows strong activity against gram-positive bacteria and weak activity against gram-negative bacteria. Flavophospholipol has been used as a feed additive for growth promotion in poultry.
Safety Profile
Poison by intravenous
route. Moderately toxic by subcutaneous
route.
