Usage
Moenomycin complex is a mixture of five major components, A, A12, C1, C3 and C4, isolated from several strains of Streptomyces in the 1960s. Moenomycins are high molecular weight phosphoglycolipids with potent antibiotic activity used in animal health. Moenomycins are the only antibiotic known to selectively inhibit the transglycosylation step catalysed by penicillin-binding protein 1b.
Description
Moenomycin complex is a mixture of moenomycins A, A
12, C
1, C
3 and C
4, which are antibiotics isolated from several strains of
Streptomyces that directly inhibit bacterial peptidoglycan glycosyltransferases.
1 The minimal inhibitory concentration of moenomycin A against various Gram-
positive bacteria ranges from 1-
100 nM.
1
Chemical Properties
Colorless, amorphous salt, a stable complex composed of four chemically similar microbial active substances, containing 1.96% phosphorus. A weak acid. Soluble in water and low-molecular-weight alcohols, insoluble in other organic solvents.
Uses
Moenomycin complex is a mixture of five major components, A, A12, C1, C3 and C4, isolated from several strains of Streptomyces in the 1960s. Moenomycins are high molecular weight phosphoglycolipids with potent antibiotic activity used in animal health. Moenomycins are the only antibiotic known to selectively inhibit the transglycosylation step catalysed by penicillin-binding protein 1b.
Definition
ChEBI: A glycophospholipid antibiotic compound with the lipid portion conjugated to a pentasaccharide fraction via a phosphate linkage.
Brand name
Flavomycin (Hoechst-Roussel).
General Description
Flavophospholipol, formerly called moenomycin, was found in the culture broth of Streptomyces bambergiensis by Hoechst in 1955. This drug is called bambermycin by INN and in the United States. It shows strong activity against gram-positive bacteria and weak activity against gram-negative bacteria. Flavophospholipol has been used as a feed additive for growth promotion in poultry.
storage
Store at -20°C, protect from light
References
[1] OSTASH B, WALKER S. Moenomycin family antibiotics: chemical synthesis, biosynthesis, and biological activity[J]. Natural Product Reports, 2010, 11: 1594-1617. DOI:
10.1039/c001461n
