Uses
ARP 100 is a potent, dual inhibitor of MMP-12/MMP-13 targets, which are a family of zinc dependent endopeptidases known to play key roles in extracellular matrix (ECM) breakdown disorders, such as the two main forms of arthritis, rheumatoid arthritis (RA) and osteoarthritis (OA).
Uses
A selective inhibitor of MMP-2
Biological Activity
Selective inhibitor of MMP-2 (IC 50 = 12 nM); displays selectivity over MMP-9, MMP-3, MMP-1 and MMP-7 (IC 50 values are 200, 4500, > 50000 and > 50000 nM respectively). Exhibits anti-invasive properties in HT1080 fibrosarcoma cells.
IC 50
MMP-2: 12 nM (IC
50); MMP-9: 0.2 μM (IC
50); MMP-3: 4.5 μM (IC
50); MMP-1: >50 μM (IC
50); MMP-7: >50 μM (IC
50)
