ARP 100 is a potent, dual inhibitor of MMP-12/MMP-13 targets, which are a family of zinc dependent endopeptidases known to play key roles in extracellular matrix (ECM) breakdown disorders, such as the two main forms of arthritis, rheumatoid arthritis (RA) and osteoarthritis (OA).
A selective inhibitor of MMP-2
Selective inhibitor of MMP-2 (IC 50 = 12 nM); displays selectivity over MMP-9, MMP-3, MMP-1 and MMP-7 (IC 50 values are 200, 4500, > 50000 and > 50000 nM respectively). Exhibits anti-invasive properties in HT1080 fibrosarcoma cells.
MMP-2: 12 nM (IC50); MMP-9: 0.2 μM (IC50); MMP-3: 4.5 μM (IC50); MMP-1: >50 μM (IC50); MMP-7: >50 μM (IC50)
