13,14-Dihydroprostaglandin E1

Description

6-keto prostaglandin F_1α (6-keto PGF_1α) is the inactive, non-enzymatic hydrolysis product of PGI₂. 6-keto PGF_1α serves as a useful marker of PGI₂ biosynthesis in vivo. When [³H]-PGI₂ is injected into healthy human males, 6.6% of the radioactivity is recovered from urine as [³H]-6-keto PGF_1α.

Uses

6-Ketoprostaglandin F1α is the stable hydrolysis product of prostacyclin (P839060), an eicosanoid which prevents the formation of platelet plugs and an effective vasodilator.

Definition

ChEBI: A prostaglandin Falpha that is prostaglandin F1alpha bearing a keto substituent at the 6-position.

IC 50

Human Endogenous Metabolite

References

[1] PACE-ASCIAK C. Isolation, structure, and biosynthesis of 6-ketoprostaglandin F1.alpha. in the rat stomach[J]. Journal of the American Chemical Society, 1976, 98 8: 2348-2349. DOI: 10.1021/ja00424a065
[2] ROY A. JOHNSON. The chemical structure of prostaglandin X (prostacyclin)[J]. Prostaglandins, 1976, 12 6: Pages 915-928. DOI: 10.1016/0090-6980(76)90126-x
[3] A R BRASH. Metabolic disposition of prostacyclin in humans.[J]. Journal of Pharmacology and Experimental Therapeutics, 1983, 226 1: 78-87.
[4] MALARVIZHI GURUSAMY. Inhibition of microsomal prostaglandin E synthase-1 ameliorates acute lung injury in mice.[J]. Journal of Translational Medicine, 2021: 340. DOI: 10.1186/s12967-021-03016-9