Description
11-
deoxy PGF
1α is a synthetic analog of PGF
1α. In whole animal studies, a dose of 32 mg/kg inhibited gastric acid secretion by 35%. 11-
deoxy PGF
1α is also known to cause rat uterine contractions at a dose 0.3 times that of PGF
1α. It also exhibits vasopressor and bronchoconstrictor activities at about half the potency of PGF
2α in guinea pigs.
Uses
11-deoxy Prostaglandin F1α (11-deoxy PGF1α) is an analog of prostaglandin F1α, exhibits side effects on intestines and causes the uterine contraction. 11-deoxy Prostaglandin F1α exhibits activity as vasopressor and bronchoconstrictor[1][2].
Definition
ChEBI: 11-Deoxy-PGF1alpha is a prostanoid.
in vivo
11-deoxy PGF1α (0-10 mg/kg, i.v., single dose) stimulates the uterine contraction in pregnant SD rats, while reveals slightly efficacy on hamster fertility[1].
| Animal Model: | pregnant Sprague-Dawley rats[1] |
| Dosage: | 0-10 mg/kg |
| Administration: | i.v., single dose |
| Result: | Stimulated uterine contraction 3 times active as PGF1α. |
References
[1] Broughton BJ, et al., Uterine stimulant action of some omega-chain modified (+)-11-deoxyprostaglandins. Prostaglandins. 1981 Jul;22(1):53-64. DOI:
10.1016/0090-6980(81)90053-8[2] Hall DW, et al., Structure-activity relationships in a series of 11-deoxy prostaglandins. Prostaglandins. 1976 Mar;11(3):573-87. DOI:
10.1016/0090-6980(76)90106-4
