11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA

Description

11β-13,14-dihydro-15-keto PGF_2α is a metabolite of PGD₂ in the 15-hydroxy PGDH pathway.^1,2 Infusion or inhalation of tritiated PGD₂ in normal males results in the appearance of peak levels of both 11β-PGF_2α, as the immediate product, and 11β-13,14-dihydro-15-keto PGF_2α in the plasma within 10 minutes.¹ Homogenates of human lung metabolize PGD₂ first to 11β-PGF_2α and then to 11β-15-keto-PGF_2α in the presence of NAD⁺, but not 11β-13,14-dihydro-15-keto PGF_2α.² Guinea pig liver and kidney homogenates metabolize PGD₂ to 11β-13,14-dihydro-15-keto PGF_2α, via 11β-PGF_2α, in the presence of NAD⁺ and NADP⁺.²

Definition

ChEBI: 11beta-13,14-dihydro-15-keto-PGF2alpha is a prostanoid.

References

1. Robinson, C., Hardy, C.C., and Holgate, S.T. The metabolism of prostaglandin D₂ after inhalation or intravenous infusion in normal men Biochim. Biophys. Acta 963(2),151-161(1988).
2. Robinson, C., Herbert, C.A., Bedwell, S., et al. The metabolism of prostaglandin D₂. Evidence for the sequential conversion by NADPH and NAD⁺ dependent pathways Biochem. Pharmacol. 38(19),3267-3271(1989).