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Costunolide

Costunolide Structure
Costunolide
  • CAS No.553-21-9
  • Chemical Name:Costunolide
  • CBNumber:CB1455816
  • Molecular Formula:C15H20O2
  • Formula Weight:232.32
  • MOL File:553-21-9.mol
Costunolide Property
Safety
  • Hazard Codes  :Xi
  • Risk Statements  :36/37/38
  • Safety Statements  :26-24/25
  • WGK Germany  :3
  • HS Code  :29322090
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H317-H319-H335
  • Precautionary statements P261-P280-P305+P351+P338
Costunolide Price More Price(50)
  • Brand: Sigma-Aldrich
  • Product number: SML0417
  • Product name : Costunolide
  • Purity: ≥97% (HPLC)
  • Packaging: 5mg
  • Price: $97.1
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: SML0417
  • Product name : Costunolide
  • Purity: ≥97% (HPLC)
  • Packaging: 25mg
  • Price: $384
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: C2921
  • Product name : Costunolide
  • Purity: >95.0%(HPLC)
  • Packaging: 100mg
  • Price: $400
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: C2921
  • Product name : Costunolide
  • Purity: >95.0%(HPLC)
  • Packaging: 25mg
  • Price: $146
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 14743
  • Product name : Costunolide
  • Purity: ≥98%
  • Packaging: 1mg
  • Price: $35
  • Updated: 2021/12/16
  • Buy: Buy

Costunolide Chemical Properties,Usage,Production

  • Description Costunolide is a germacranolide sesquiterpene lactone extracted from costus oil. With alantolactone and dehydrocostuslactone, it is a component of lactone mix used to elicit reactions in Compositae-sensitive patients. An erythema-multiform-like occupational contact dermatitis case occurred in a chemistry student after accidental exposure to costus oil (CJ Le Coz & JP Lepoittevin, unpublished results).
  • Chemical Properties White powder
  • Uses A sequiterpene lactone that inhibits telomerase
  • Uses (+)-Costunolide is an inhibitor of osteoclast differentiation, acting as an anti-inflammatory and anti-oxidant agent. It is a sesquiterpene lactone which mediates apoptosis.
  • Uses Costunolide is the oil extracted from Saussurea lappa is used in perfumery and in the Orient for all kinds of diseases.
  • Definition ChEBI: A germacranolide with anthelminthic, antiparasitic and antiviral activities.
  • Biological Activity Inhibitor of human telomerase activity (IC 50 = 65 μ M in MCF-7 breast cancer cells). Suppresses proliferation and induces apoptosis in a variety of human tumor cell lines. Selectively blocks endothelial cell proliferation induced by VEGF. Inhibits expression of iNOS and IL-1 β and disrupts NF- κ B activation. Displays anti-inflammatory, antifungal and antiviral properties.
  • Contact allergens This germacranolide sesquiterpene lactone is extracted from costus oil. With alantolactone and dehydrocostunolide, it is a component of lactone mix used to elicit reactions in patients sensitive to Asteraceae-Compositae. An erythema-multiform-like occupational contact dermatitis case occurred in a chemical student after an accidental exposure to costus oil.
Costunolide Preparation Products And Raw materials
Raw materials
Preparation Products
Global(233)Suppliers
  • Supplier:
    career henan chemical co
  • Tel:+86-0371-55982848
  • Fax:
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  • Country:China
  • ProdList:29953
  • Advantage:58
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  • Supplier:
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  • Supplier:
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  • Fax:
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  • Country:CHINA
  • ProdList:37282
  • Advantage:58
553-21-9, CostunolideRelated Search:
  • Costundide 553-21-9
  • (3AS,6E,10E,11AR)-3A,4,5,8,9,11A-HEXAHYDRO-6,10-DIMETHYL-3-METHYLENE-CYCLODECA[B]FURAN-2(3H)-ONE
  • COSTUNOLIDE
  • (e,e)-6-alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oicacidgamma-lactone
  • costunolid
  • germacra-1(10),4,11(13)-trien-12-oicacid,6-alpha-hydroxy-,gamma-lactone,(e,
  • Costunolide (NSC-106404)
  • Costunolide, 98%, from Saussurea costus (Falc.) Lipsch.
  • Cyclodeca[b]furan-2(3H)-one, 3a,4,5,8,9,11a-hexahydro-6,10-dimethyl-3- methylene-, [3aS-(3aR*,6E,10E,11aS*)]-
  • CUSTUNOLIDE
  • Cyclodeca[b]furan-2(3H)-one,3a,4,5,8,9,11a-
  • hexahydro-6,10-dimethyl-3-methylene-,(3aS,6E,10E,11aR)-
  • (3aS,6E,10E)-3aβ,4,5,8,9,11aβ-Hexahydro-6,10-dimethyl-3-methylenecyclodeca[b]furan-2(3H)-one
  • (3aS,6E,10E)-3-Methylene-6,10-dimethyl-2,3,3aβ,4,5,8,9,11aα-octahydrocyclodeca[b]furan-2-one
  • Costulide
  • Costunlide
  • (3aS,6E,10E,11aR)-6,10-Dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[d]furan-2-one
  • COSTUNDIDE
  • NSC 106404
  • Costunolide, froM Auckiandialappa Decne.
  • (3aS,6E,10E,11aR)-6,10-dimethyl-3-methylene-3,3a,4,5,8,9-hexahydrocyclodeca[b]furan-2(11aH)-one
  • Costunolide, >=98%
  • Costunolide CRS
  • Cyclodeca[b]furan-2(3H)-one, 3a,4,5,8,9,11a-hexahydro-6,10-dimethyl-3-methylene-, (3aS,6E,10E,11aR)-
  • Costunolide,(S)
  • (3aS,6E,10E,11aR)-6,10-Dimethyl-3-methylene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2(3H)-one
  • 553-21-9
  • Sesquiterpenoids
  • Inhibitors
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • chiral
  • Miscellaneous Natural Products