Chemical Properties
White powder
Uses
A sequiterpene lactone that inhibits telomerase
Definition
ChEBI: A germacranolide with anthelminthic, antiparasitic and antiviral activities.
Biological Activity
Inhibitor of human telomerase activity (IC 50 = 65 μ M in MCF-7 breast cancer cells). Suppresses proliferation and induces apoptosis in a variety of human tumor cell lines. Selectively blocks endothelial cell proliferation induced by VEGF. Inhibits expression of iNOS and IL-1 β and disrupts NF κ B activation. Displays anti-inflammatory, antifungal and antiviral properties.
Description
Costunolide is a germacranolide sesquiterpene lactone
extracted from costus oil. With alantolactone and
dehydrocostuslactone, it is a component of lactone mix
used to elicit reactions in Compositae-sensitive patients.
An erythema-multiform-like occupational contact
dermatitis case occurred in a chemistry student
after accidental exposure to costus oil (CJ Le Coz & JP
Lepoittevin, unpublished results).
General Description
Costunolide has anti-ulcer and antipyretic properties. It inhibits the cellular proliferation of melanin, human lamin-B by farnesyl-protein transferase (FPTase) and protein tyrosine phosphatase 1B (hPTP1B). Costunolide has strong larvicidal activity against A.albopictus. It inhibits the expression of inducible nitric oxide synthase and DNA-binding activity of nuclear factor kappa B subunit (NF-κB). It might function as a natural herbicide.
Biochem/physiol Actions
Costunolide is a sesquiterpene lactone originally isolated from plants widely used in many herbal medicines. It has a variety of effects. Costunolide is a potent inducer of apoptosis, a potent anti-cancer agent, has anti-inflammatory, anti-viral, anti-fungal, antimycobacterial activity and has been shown to inhibit telomerase activity.
storage
Store at -20°C, sealed storage, away from moisture and light
