Originator
Nepresol,Novartis
Uses
Ophthazin is an antihypertensive agent of the hydrazine class used during pregnancies in dialysis patients with familial mediterranean fever and cystinosis under hemodialysis.
Definition
ChEBI: Dihydralazine is a member of phthalazines.
Manufacturing Process
115 parts of hydrazine hydrate in 80 parts 50% acetic acid were added to 128
parts of phthalic acid dinitrile in 250 parts dioxane. The mixture was heated at
the temperature 95°C for 3 hours with stirring. After 20 minutes the
crystallization and discharging of NH3 began. The orange needles were filtered
off after cooling. The product was washed with dioxane and ethanol and
recrystallized from 3000 parts of water to yield 110 parts colorless needles of
1,4-dihydrazino-phthalazine; MP: 191°-193°C (decomp.). The crystals were
getting a little orange color by standing because of a reaction with an air
oxygen.
Therapeutic Function
Antihypertensive
Safety Profile
Poison by intravenous route. Anexperimental teratogen. When heated to decomposition itemits toxic fumes of NOx.
