ChemicalBook CAS DataBase List 484-23-1

484-23-1

Name	Ophthazin
CAS	484-23-1
EINECS(EC#)	207-605-0
Molecular Formula	C8H10N6
MDL Number	MFCD01250766
Molecular Weight	190.21
MOL File	484-23-1.mol

Chemical Properties

Melting point	180°C (rough estimate)
Boiling point	315.71°C (rough estimate)
density	1.3243 (rough estimate)
refractive index	1.8100 (estimate)
pka	3?+-.0.20(Predicted)
color	Orange crystals from H2O

Safety Data

HS Code	2933998090
Toxicity	LD50 i.p. in rats: 1084 mmol/kg (Steiner) less more

Raw materials And Preparation Products

Hazard Information

Chemical Properties

Dihydralazine (trade name: Ophthazin; CAS No. 484-23-1), also known as 1,4-dihydrazinylphthalazine, occurs as orange, needle-like crystals and decomposes at approximately 180 °C. Its sulfate salt (CAS No. 2740-03-6), the form commonly used in clinical practice, is obtained as white, needle-like crystals with a decomposition point of 233 °C. It is slightly soluble in boiling water and sparingly soluble in water or ethanol.

Originator

Nepresol,Novartis

Uses

Ophthazin is an antihypertensive agent of the hydrazine class used during pregnancies in dialysis patients with familial mediterranean fever and cystinosis under hemodialysis.

Definition

ChEBI: Dihydralazine is a member of phthalazines.

Preparation

Dihydralazine is prepared from dichlorophthalazine via sequential substitution and hydrazination reactions.

Manufacturing Process

115 parts of hydrazine hydrate in 80 parts 50% acetic acid were added to 128 parts of phthalic acid dinitrile in 250 parts dioxane. The mixture was heated at the temperature 95°C for 3 hours with stirring. After 20 minutes the crystallization and discharging of NH3 began. The orange needles were filtered off after cooling. The product was washed with dioxane and ethanol and recrystallized from 3000 parts of water to yield 110 parts colorless needles of 1,4-dihydrazino-phthalazine; MP: 191°-193°C (decomp.). The crystals were getting a little orange color by standing because of a reaction with an air oxygen.

Therapeutic Function

Antihypertensive

Safety Profile

Poison by intravenous route. Anexperimental teratogen. When heated to decomposition itemits toxic fumes of NOx.

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