Identification Chemical Properties Safety Data Raw materials And Preparation Products Hazard Information Material Safety Data Sheet(MSDS) Questions And Answer Spectrum Detail Well-known Reagent Company Product Information Supplier Related Products


Name Hydrochlorothiazide
CAS 58-93-5
EINECS(EC#) 200-403-3
Molecular Formula C7H8ClN3O4S2
MDL Number MFCD00051765
Molecular Weight 297.74
MOL File 58-93-5.mol

Chemical Properties

Appearance White Solid
Melting point  273 °C
Boiling point  577.0±60.0 °C(Predicted)
density  1.6761 (rough estimate)
refractive index  1.6100 (estimate)
Fp  9℃
storage temp.  2-8°C
solubility  Very slightly soluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent). It dissolves in dilute solutions of alkali hydroxides
form  solid
pka 7.9, 9.2(at 25℃)
color  White to Off-White
Stability: Stable. Incompatible with strong oxidizing agents.
Water Solubility  722mg/L(25 ºC)
Usage A carbonic anhydrase inhibitor
λmax 318nm(H2O)(lit.)
Merck  14,4781
BRN  625101
CAS DataBase Reference 58-93-5(CAS DataBase Reference)
IARC 2B (Vol. 50, 108) 2016
NIST Chemistry Reference 6-Chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide(58-93-5)
EPA Substance Registry System 58-93-5(EPA Substance)

Safety Data

Hazard Codes  Xi,T,F
Risk Statements 
R22:Harmful if swallowed.
R42/43:May cause sensitization by inhalation and skin contact .
R36/38:Irritating to eyes and skin .
R23/25:Toxic by inhalation and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Statements 
S22:Do not breathe dust .
S24:Avoid contact with skin .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S33:Take precautionary measures against static discharges .
S16:Keep away from sources of ignition-No smoking .
S7:Keep container tightly closed .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S27:Take off immediately all contaminated clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
RIDADR  UN 1230 3/PG 2
WGK Germany  2
RTECS  DK9100000
Hazard Note  Irritant
HS Code  29350090
Safety Profile
Poison bp intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Human systemic effects by ingestion: sodum level changes, chlorine level changes, acute pulmonary edema, nausea or vomiting. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. A duetic. When heated to decomposition it emits very toxic fumes of SOx, Cl-, and NOx.
Hazardous Substances Data 58-93-5(Hazardous Substances Data)
LD50 in mice (mg/kg): 590 i.v.; >8000 orally (Piala)

Raw materials And Preparation Products

Hazard Information

Material Safety Data Sheet(MSDS)

Questions And Answer