Description
3-Amino-5-bromobenzotrifluoride is an organic synthetic reagent or pharmaceutical intermediate component used in the synthesis of other organic compounds such as 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, fluorinated 2-benzylphthalazine-1 (2H)-one, 1-phthalazinamine and 1-alkoxy/benzyloxyphthalazine derivatives. It can also be used to prepare the targeted anti-cancer drug Nilotinib, which can be used to treat chronic granulocytic leukaemia (CML).
Chemical Properties
White solid
Uses
3-Amino-5-bromobenzotrifluoride may be used in the synthesis of 3-(4-methyl-1
H-imidazol-1-yl)-5-(trifluoromethyl)aniline.
Hazard
3-Amino-5-bromobenzotrifluoride has acute toxicity (oral, inhalation,dermal), it causes skin irritation and eye irritation.
Synthesis
3-Amino-5-bromotrifluorotoluene was prepared from 4-bromo-2-trifluorotoluene by acetylation, nitration, deacetylation, deamination, and reduction.
