Uses
8-Br-GTP, a GTP analog, is a competitive FtsZ polymerization and GTPase activity (Ki of 31.8 μM) inhibitor. 8-Br-GTP can be used for nucleic acid modification[1].
References
[1] Tilman Lppchen, et al. GTP analogue inhibits polymerization and GTPase activity of the bacterial protein FtsZ without affecting its eukaryotic homologue tubulin. Biochemistry. 2005 May 31;44(21):7879-84. DOI:
10.1021/bi047297o[2] Jozef Hritz, et al. Optimization of replica exchange molecular dynamics by fast mimicking. J Chem Phys. 2007 Nov 28;127(20):204104. DOI:
10.1063/1.2790427
