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Doxorubicin hydrochloride Structure

Doxorubicin hydrochloride

Chemical Properties

Melting point 216 °C (dec.)(lit.)
alpha  D20 +248±2° (c = 0.1 in methanol)
storage temp.  2-8°C
solubility  Soluble in DMSO at 100 mg/ml; very poorly soluble in ethanol; soluble in water at 10 mg/ml with slight warming.
pka pKa 8.25±0.60 (Uncertain);8.43±0.70 (Uncertain);11.9±0.4 (Uncertain);12.95±0.1 (Uncertain);13.8±0.70 (Uncertain)
form  solid
color  orange to dark red
Water Solubility  Soluble in water.
λmax 497nm(H2O)(lit.)
Merck  14,3439
BRN  4229251
Stability Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
InChIKey MWWSFMDVAYGXBV-RUELKSSGSA-N
CAS DataBase Reference 25316-40-9(CAS DataBase Reference)
NCI Dictionary of Cancer Terms doxorubicin hydrochloride
FDA UNII 82F2G7BL4E
NCI Drug Dictionary doxorubicin hydrochloride
Proposition 65 List Doxorubicin Hydrochloride (Adriamycin)
EPA Substance Registry System Doxorubicin hydrochloride (25316-40-9)

Safety

Symbol(GHS) GHS hazard pictogramsGHS hazard pictograms
Signal wordDanger
Hazard statements H302-H340-H350-H360FD
Precautionary statements P201-P202-P264-P270-P301+P312-P308+P313
Hazard Codes  T,T+,Xi
Risk Statements  45-22-40-26/27/28-36/38
Safety Statements  53-45-36/37/39-22-7/9
WGK Germany  3
RTECS  QI9295900
10-21
HS Code  29419090
Toxicity LD50 i.v. in mice: 21.1 mg/kg (Bertazzoli, 1970)
NFPA 704:
0
1 0

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