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Doxorubicin hydrochloride Structure

Doxorubicin hydrochloride

Chemical Properties

Melting point 216 °C (dec.)(lit.)
alpha  D20 +248±2° (c = 0.1 in methanol)
storage temp.  2-8°C
solubility  Soluble in DMSO at 100 mg/ml; very poorly soluble in ethanol; soluble in water at 10 mg/ml with slight warming.
pka pKa 8.25±0.60 (Uncertain);8.43±0.70 (Uncertain);11.9±0.4 (Uncertain);12.95±0.1 (Uncertain);13.8±0.70 (Uncertain)
form  solid
color  orange to dark red
Water Solubility  Soluble in water.
λmax 497nm(H2O)(lit.)
Merck  14,3439
BRN  4229251
Stability Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
CAS DataBase Reference 25316-40-9(CAS DataBase Reference)
NCI Dictionary of Cancer Terms doxorubicin hydrochloride
NCI Drug Dictionary doxorubicin hydrochloride
Proposition 65 List Doxorubicin Hydrochloride (Adriamycin)
EPA Substance Registry System Doxorubicin hydrochloride (25316-40-9)


Signal wordDanger
Hazard statements H302-H340-H350-H360FD
Precautionary statements P201-P202-P264-P270-P301+P312-P308+P313
Hazard Codes  T,T+,Xi
Risk Statements  45-22-40-26/27/28-36/38
Safety Statements  53-45-36/37/39-22-7/9
WGK Germany  3
RTECS  QI9295900
HS Code  29419090
Toxicity LD50 i.v. in mice: 21.1 mg/kg (Bertazzoli, 1970)
NFPA 704:
1 0

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