pellitorine

Uses

Pellitorine is an ACAT (Acyl-CoA cholesteryl acyl transferase) and α-Glucosidase inhibitor.

Definition

ChEBI: A natural product found in Piper sarmentosum.

Synthesis Reference(s)

Synthetic Communications, 18, p. 77, 1988 DOI: 10.1080/00397918808057822
Tetrahedron Letters, 29, p. 3949, 1988 DOI: 10.1016/S0040-4039(00)80390-1

Biological Activity

Pellitorine is an α-Glucosidase inhibitor isolated from the roots of Piper Nigrum th at exhibit anti-diabetic, anti-cancer, anti-bacterial and anti-inflammatory properties. Pellitorine is an AC at (Acyl-CoA cholesteryl acyl transferase) inhibitor th at inhibits cholesterol esterification in HepG2 cells. Also pellitorine exhibit potent larvicide activity in mosquito by Inhibition of gene expression encoding V-type H+-ATPase and aquaporine 4. Some new research suggests th at anti-adipogenic activity of pellitorine depends on TRPV1.

storage

+4°C