Feature reaction of phloroglucinol Chemical properties Uses Production method Hazards & Safety Information
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Phloroglucinol

Feature reaction of phloroglucinol Chemical properties Uses Production method Hazards & Safety Information
Phloroglucinol Structure
Phloroglucinol
  • CAS No.108-73-6
  • Chemical Name:Phloroglucinol
  • CBNumber:CB0667672
  • Molecular Formula:C6H6O3
  • Formula Weight:126.11
  • MOL File:108-73-6.mol
Phloroglucinol Property
  • Melting point: :215-220 °C
  • Boiling point: :194.21°C (rough estimate)
  • Density  :0.801 g/mL at 20 °C
  • refractive index  :n20/D 1.365
  • Flash point: :14 °C
  • storage temp.  :Store below +30°C.
  • solubility  :Soluble in diethyl ether, ethanol and pyridine.
  • form  :Crystalline Powder
  • pka :pK1:8.45(0);pK2:8.88(-1) (25°C)
  • color  :White to light beige
  • Water Solubility  :11.17g/L(room temperature)
  • Sensitive  :Light Sensitive & Hygroscopic
  • Merck  :14,7328
  • BRN  :1341907
  • InChIKey :QCDYQQDYXPDABM-UHFFFAOYSA-N
  • CAS DataBase Reference :108-73-6(CAS DataBase Reference)
  • EWG's Food Scores :3-6
  • FDA UNII :DHD7FFG6YS
  • ATC code :A03AX12
  • NIST Chemistry Reference :1,3,5-Benzenetriol(108-73-6)
  • EPA Substance Registry System :1,3,5-Benzenetriol (108-73-6)
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H317-H319-H335
  • Precautionary statements P280-P305+P351+P338-P261-P264-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P280a-P304+P340-P405-P501a
Phloroglucinol Price More Price(46)
  • Brand: Sigma-Aldrich
  • Product number: 79330
  • Product name : Phloroglucinol
  • Purity: ≥99.0% (HPLC)
  • Packaging: 25g
  • Price: $30.4
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 1.07069
  • Product name : Phloroglucinol
  • Purity: (1,3,5-trihydroxybenzene) for analysis
  • Packaging: 25 g
  • Price: $51.71
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 8.18887
  • Product name : Phloroglucinol
  • Purity: for synthesis
  • Packaging: 100 g
  • Price: $85.56
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 79330
  • Product name : Phloroglucinol
  • Purity: ≥99.0% (HPLC)
  • Packaging: 100g
  • Price: $86.5
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: P0249
  • Product name : Phloroglucinol Anhydrous
  • Purity: >99.0%(HPLC)
  • Packaging: 25g
  • Price: $32
  • Updated: 2021/12/16
  • Buy: Buy

Phloroglucinol Chemical Properties,Usage,Production

  • Feature reaction of phloroglucinol Reaction of formaldehyde with phloroglucinol under alkaline conditions generates orange compound. The colorimetric assay determination of this compound at the maximum absorption wavelength of 460 nm, can be used to detect low or trace formaldehyde in textile and garment.
    Since phloroglucinol may occur enol and keto tautomers, it can react with ammonia according following reaction:
    Under the influence of ammonia, 1,3,5-Benzenetriamine can be obtained by keto reaction of phloroglucinol
    Under the influence of ammonia, 1,3,5-Benzenetriamine can be obtained by keto reaction of phloroglucinol, while this amine can also hydrolyze in aqueous acid to generate phloroglucinol. Besides phloroglucinol can also have enol reaction.
    phloroglucinol can also have enol reaction
    The information above is edited by Andy from Chemicalbook.
  • Chemical properties This product is a white or light yellow crystal or crystalline powder with melting point of 218 ℃. Usually it carries two molecular crystallization water ([6099-90-7]) and converts into anhydrous at 110 ℃. It can be dissolved in 100 parts of water, 10 parts of ethanol, and 0.5 parts of pyridine and is soluble in ether. Besides It partially decomposes when sublimation, and changes its color when exposed to the light. In addition it tastes sweet.
  • Uses It can be used in verifications of antimony, arsenic, cerium, chromate, chromium, gold, iron, mercury, nitrites, osmium, palladium, tin, vanadium, vanillin and lignin, and measurement of furfural, pentose, pentosan, methanol, chloral hydrate, turpentine, Lignified cell tissues, free acid in gastric juice (HCl) and decalcified bone specimens. Besides it can also be used as biological reagent dyes.
  • Production method 2,4,6-aminobenzoic acid can be obtained by 2,4,6-trinitrobenzoic acid`s reduction of zinc particles. After its dilute solution was heated at reflux for 20h, acidified with hydrochloric acid, cooled and crystallized, phloroglucinol can be obtained with a yield of 46-53%.
  • Hazards & Safety Information Category: Toxic substances
    Toxicity grade: Moderate toxicity
    Acute toxicity: oral-rat LD50: 4000 mg/kg; Oral-Mouse LD50: 4550 mg/kg
    Flammability hazard characteristics: Combustible fire burning can cause smoke irritation
    Storage characteristics: Ventilated, low-temperature and dry warehouse; and separately with oxidants
    Extinguishing agents: Carbon dioxide, foam, sand and water mist
  • Description Phloroglucinol is a naturally occurring phenol that exhibits diverse biological activities. Phloroglucinol protects V79-4 Chinese hamster lung fibroblast cells from oxidative stress and inhibits lipid peroxidation by scavenging reactive oxygen species (ROS). It induces apoptosis in HT-29 human colon cancer cells and inhibits metastasis of BT549 and MDA-MB-231 human breast cancer cells. Phloroglucinol protects primary neurons from β-amyloid-induced dendritic spine loss in vitro and shortens the latency to find the platform in a Morris water maze test in an Alzheimer’s disease (AD) mouse model. Phloroglucinol has been used to stain histological plant sections and in the synthesis of numerous natural products. Phloroglucinol slows the frequency and decreases the amplitude of contraction in isolated rabbit and rat intestine at a concentration of 100 and 1 μM, respectively. Formulations containing phloroglucinol have been used as antispasmodics.
  • Chemical Properties white to light yellow crystal
  • Uses Antispasmodic.
  • Uses Phloroglucinol (1,3,5-trihydroxybenzene) is the core structure of a large family of substituted phenolics with broad, albeit weak, biological activity. Phloroglucinol is a useful metabolite for HPLC/DAD and bioassay dereplication.
  • Uses diagnostic aid growth hormone releasing factor
  • Uses A potentially useful hygroscopic biochemical.
  • Definition ChEBI: A benzenetriol with hydroxy groups at position 1, 3 and 5.
  • General Description
    Phloroglucinol is a trihydroxybenzene with antithrombotic, profibrinolytic, antimicrobial, antimalarial, cancer chemopreventive, anti-HIV and anti-leishmanial activities. Phloroglucinol (PG) is a biosynthetic precursor of the 2,4-diacetylphloroglucinol (DAPG) an antibiotic against soil-borne diseases. Phloroglucinol is a useful intermediate because it is polyfunctional.
  • Safety Profile Moderately toxic by subcutaneous and intraperitoneal routes. Mildly toxic by ingestion. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. Used in diazo-type printing and textile dyeing, in microscopy as a bone specimen decalcifier
  • Purification Methods Crystallise the triol from water, and store it in the dark under nitrogen. [Beilstein 6 IV 7361.]
Phloroglucinol Preparation Products And Raw materials
Raw materials
Preparation Products
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108-73-6, PhloroglucinolRelated Search:
  • 6,17-alpha Epoxypregnenolone
  • Phloroglucinol >=99.0% (HPLC)
  • Floroglucin
  • Floroglucinol
  • Phloroglucine
  • Spasfon-Lyoc
  • s-Trihydroxybenzene
  • sym-Trihydroxybenzene
  • Phloroglucinol, >=98%
  • PHLOROGLUCINOL TS
  • PHLOROGLUCIN
  • PHLOROGLUCINOL
  • ?hloroglucin
  • 1,3,5-trihydroxy-benzen
  • 1,3,5-Trihydroxycyclohexatriene
  • 5-Oxyresorcinol
  • 5-Oxyresorcinolphloroglucin
  • Benzene, 1,3,5-trihydroxy-
  • Benzene, trihydroxy
  • Phloroglucinol Standard
  • Phloroglucin Anhydrous
  • Phloroglucinol, anhydrous, 99+% 25GR
  • 1,3,5-Trihydroxybenzene,Phloroglucinol Anhydrous and Dihydrate
  • 1,3,-Trihydroxybenzene
  • Anhydrous Phloroglucinol
  • benzene-1,3,5-triol(phloroglucinol)
  • orog
  • ucinoL
  • 1,2,5-TRIHYDROXYBENZENE
  • 1,3,5-TRIHYDROXYBENZENE
  • 1,3,5-TRIHYDROXYBENZENE ANH
  • 1,3,5-THB
  • 1,3,5-BENZENETRIOL
  • AKOS BBS-00004257
  • 5-HYDROXYRESORCINOL
  • 3,5-DIHYDROXYPHENOL
  • TRIHYDROXYBENZENE
  • Phlorogluctinol(Anhydrous)
  • phloroglucinol Anhy
  • phloroglucinol dihydrate MSDS
  • PHLOROGLUCINOL SOLUTION 1% IN ETHANOL
  • Phloroglucinol solution
  • PHLOROGLUCINOL, FREE OF DIRESORCIN
  • PhloroglucinolGr-(1,3,5-Trihydroxybenzene)
  • PhloroglucinolGr
  • 1,3,5-Trihydroxybenzene(Anhydrous)
  • Phloroglucinol, anhydrous, 99+%
  • benzene,trihydroxy
  • Benzene-1,3,5-triol
  • Benzene-s-triol
  • Dilospan S
  • dilospans
  • Phlorolglucine
  • 1,3,5-benzenetriol, anhydrous
  • 1.3.5-Trihydroxybenzene,Phloroglucinol
  • FLUOROGLUCINOL
  • 1,3,5-TRIHYDROXYBENZENE ANHYDRATE MIN 99%
  • Phloroglucinol, 99+%, anhydrous