Description References
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TETRODOTOXIN

Description References
TETRODOTOXIN Structure
TETRODOTOXIN
  • CAS No.4368-28-9
  • Chemical Name:TETRODOTOXIN
  • CBNumber:CB0489528
  • Molecular Formula:C11H17N3O8
  • Formula Weight:319.27
  • MOL File:4368-28-9.mol
TETRODOTOXIN Property
  • Melting point: :280 °C (decomp)
  • alpha  :D25 -8.64° (c = 8.55 in dil acetic acid)
  • Boiling point: :458.31°C (rough estimate)
  • Density  :1.3768 (rough estimate)
  • refractive index  :1.5700 (estimate)
  • storage temp.  :2-8°C
  • solubility  :H2O: stable at pH 4-5 if stored frozensoluble
  • pka :8.76 (water); 9.4 (50% alc)
  • form  :powder
  • color  :white
  • Merck  :13,9318
  • CAS DataBase Reference :4368-28-9(CAS DataBase Reference)
  • EPA Substance Registry System :Tetrodotoxin (4368-28-9)
Safety
  • Hazard Codes  :T+
  • Risk Statements  :26/27/28
  • Safety Statements  :22-36/37/39-45-36/37-28
  • RIDADR  :UN 3462 6.1/PG 1
  • WGK Germany  :3
  • RTECS  :IO1450000
  • F  :10-18
  • HazardClass  :6.1(a)
  • PackingGroup  :I
  • HS Code  :30029090
  • Toxicity :LD50 i.p. in mice: 10 mg/kg (Kao, Fuhrman)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
TETRODOTOXIN Price More Price(2)
  • Brand: Cayman Chemical
  • Product number: 14964
  • Product name : Tetrodotoxin Citrate
  • Purity: ≥98%
  • Packaging: 1mg
  • Price: $179
  • Updated: 2020/06/24
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 14963
  • Product name : Tetrodotoxin
  • Purity: ≥98%
  • Packaging: 1mg
  • Price: $189
  • Updated: 2021/03/22
  • Buy: Buy

TETRODOTOXIN Chemical Properties,Usage,Production

  • Description Tetraodotoxin is a kind of extremely potent toxin which exists in the liver and sex organs of some fishes including pufferfish, porcupine fish, ocean sunfish, and toadfish as well as some kind of amphibian, octopus and shellfish species. It is also produced by some bacteria such as Pseudomonas and Vibrio. Tetraodotoxin is extremely toxic to human, interfering with the transmission of signals of nerves to muscles and further causing paralysis of the body muscle. It can be fatal in some cases. Its mechanism of action is inhibiting the firing of action potentials in nerves through binding to the voltage-gated sodium channels in nerve cell membrane and blocking the passages of sodium ions into the nerve cell. People should wear proper protective equipment upon operations and should be subject to proper treatment upon suffering from it. However, it has been under investigation on the treatment of chronic and breakthrough pain in advanced cancer patients.
  • References https://www.cdc.gov/niosh/ershdb/emergencyresponsecard_29750019.html https://en.wikipedia.org/wiki/Tetrodotoxin
  • Chemical Properties white powder
  • Uses Tetrodotoxin is a highly selective, reversible sodium channel blocker.
  • Definition ChEBI: A quinazoline alkaloid that is a marine toxin isolated from fish such as puffer fish. It has been shown to exhibit potential neutotoxicity due to its ability to block voltage-gated sodium channels.
  • Biological Activity Selective inhibitor of Na + channel conductance. Binding is reversible and of high affinity (K d = 1-10 nM). Blocks in a use-dependent manner.
  • Safety Profile Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. When heated to decomposition it emits toxic fumes of Nox.
TETRODOTOXIN Preparation Products And Raw materials
Raw materials
Preparation Products
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  • C11H17N3O8
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • Voltage-gated Ion Channels
  • Sodium Channel Modulators
  • Monovalent Ion Channels
  • Other Sodium Channel Modulators
  • Ion Channels
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract