Basic information Description References Safety Related Supplier
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TETRODOTOXIN

Basic information Description References Safety Related Supplier
TETRODOTOXIN Basic information
TETRODOTOXIN Chemical Properties
  • Melting point:280 °C (decomp)
  • alpha D25 -8.64° (c = 8.55 in dil acetic acid)
  • Boiling point:458.31°C (rough estimate)
  • Density 1.3768 (rough estimate)
  • refractive index 1.5700 (estimate)
  • storage temp. 2-8°C
  • solubility H2O: stable at pH 4-5 if stored frozensoluble
  • pka8.76 (water); 9.4 (50% alc)
  • form powder
  • color white
  • Merck 13,9318
  • CAS DataBase Reference4368-28-9(CAS DataBase Reference)
  • EPA Substance Registry SystemTetrodotoxin (4368-28-9)
Safety Information
  • Hazard Codes T+
  • Risk Statements 26/27/28
  • Safety Statements 22-36/37/39-45-36/37-28
  • RIDADR UN 3462 6.1/PG 1
  • WGK Germany 3
  • RTECS IO1450000
  • 10-18
  • HazardClass 6.1(a)
  • PackingGroup I
  • HS Code 30029090
  • ToxicityLD50 i.p. in mice: 10 mg/kg (Kao, Fuhrman)
MSDS
TETRODOTOXIN Usage And Synthesis
  • DescriptionTetraodotoxin is a kind of extremely potent toxin which exists in the liver and sex organs of some fishes including pufferfish, porcupine fish, ocean sunfish, and toadfish as well as some kind of amphibian, octopus and shellfish species. It is also produced by some bacteria such as Pseudomonas and Vibrio. Tetraodotoxin is extremely toxic to human, interfering with the transmission of signals of nerves to muscles and further causing paralysis of the body muscle. It can be fatal in some cases. Its mechanism of action is inhibiting the firing of action potentials in nerves through binding to the voltage-gated sodium channels in nerve cell membrane and blocking the passages of sodium ions into the nerve cell. People should wear proper protective equipment upon operations and should be subject to proper treatment upon suffering from it. However, it has been under investigation on the treatment of chronic and breakthrough pain in advanced cancer patients.
  • Referenceshttps://www.cdc.gov/niosh/ershdb/emergencyresponsecard_29750019.html https://en.wikipedia.org/wiki/Tetrodotoxin
  • Chemical Propertieswhite powder
  • UsesTetrodotoxin is a highly selective, reversible sodium channel blocker.
  • DefinitionChEBI: A quinazoline alkaloid that is a marine toxin isolated from fish such as puffer fish. It has been shown to exhibit potential neutotoxicity due to its ability to block voltage-gated sodium channels.
  • Biological ActivitySelective inhibitor of Na + channel conductance. Binding is reversible and of high affinity (K d = 1-10 nM). Blocks in a use-dependent manner.
  • Safety ProfilePoison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. When heated to decomposition it emits toxic fumes of Nox.
TETRODOTOXIN(4368-28-9)Related Product Information
TETRODOTOXINSupplierMore
  • Company Name:Shanghai BeiZhuo Biotech Co., Ltd. Gold
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  • Company Name:Kingfirst Chemical (Nanjing) Co.,Ltd Gold
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  • Company Name:J & K SCIENTIFIC LTD.
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  • Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
  • Tel:18930552037 821-50328103-801
  • Email:3bsc@sina.com
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  • Company Name:Ascent Scientific
  • Tel:4401179829988
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