ChemicalBook CAS DataBase List 4368-28-9

4368-28-9

Name	TETRODOTOXIN
CAS	4368-28-9
EINECS(EC#)	224-458-8
Molecular Formula	C11H17N3O8
MDL Number	MFCD00213719
Molecular Weight	319.27
MOL File	4368-28-9.mol

Synonyms

FUGU POISON OCTAHYDRO-12-(HYDROXYMETHYL)-2-IMINO-5,9:7,10A-DIMETHANO-10AH-[1,3]DIOXOCINO[6,5-D]PYRIMIDINE-4,7,10,11,12-PENTOL TETRODOTOXIN TETRODOTOXIN, FUGU SPECIES TTX 10abeta,11s*,12s*))-10alph 12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10ah-(1,3)dioxocino(6,5-d)pyri 4aalpha,5alpha,7alpha,9alpha,10alpha,10abeta,11s*,12s*))-octahydro-(4r-(4alph 5,9:7,10a-dimethano-10ah-(1,3)dioxocino(6,5-d)pyrimidine-4,7,10,11,12-pentol, 5,9:7,10a-dimethano-10ah-(1,3)dioxocino(6,5-d)pyrimidine-4,7,10,11,12-pentol,o 5-d)pyrimidine-4,7,10,11,12-pentol babyloniajaponicatoxin1 bjt-1 ctahydro-12-(hydroxymethyl)-2-imino-,(4r-(4alpha,4aalpha,5alpha,7alpha,9alpha, maculotoxin midine-4,7,10,11,12-pentol octahydro-12-(hydroxymethyl)-2-imino- octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10ah-(1,3)dioxocino(6, spheroidine tarichatoxin

Chemical Properties

Appearance	white powder
Melting point	280 °C (decomp)
alpha	D25 -8.64° (c = 8.55 in dil acetic acid)
Boiling point	458.31°C (rough estimate)
density	1.3768 (rough estimate)
refractive index	1.5700 (estimate)
storage temp.	2-8°C
solubility	H₂O: stable at pH 4-5 if stored frozensoluble
form	powder
pka	8.76 (water); 9.4 (50% alc)
color	white
Merck	13,9318
Stability:	Acid Sensitive, Hygroscopic
CAS DataBase Reference	4368-28-9(CAS DataBase Reference)
EPA Substance Registry System	Tetrodotoxin (4368-28-9)

Safety Data

Hazard Codes	T+
Risk Statements	R26/27/28:Very Toxic by inhalation, in contact with skin and if swallowed . less more
Safety Statements	S22:Do not breathe dust . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . less more
RIDADR	UN 3462 6.1/PG 1
WGK Germany	3
RTECS	IO1450000
F	10-18
HazardClass	6.1(a)
PackingGroup	I
HS Code	30029090
Safety Profile	Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. When heated to decomposition it emits toxic fumes of Nox. less more
Hazardous Substances Data	4368-28-9(Hazardous Substances Data)
Toxicity	LD50 i.p. in mice: 10 mg/kg (Kao, Fuhrman) less more

Hazard Information

Chemical Properties

white powder

Uses

Tetrodotoxin is a highly selective, reversible sodium channel blocker.

Uses

TTX is an extremely popular chemical tool in the physiological and pharmacological laboratories since discovery of its channel blocking action in the early 1960s. Some potential therapeutic uses include suppressing pain in cancer patients, preventing ischemic damage of the brain that follows stroke, relieving the symptoms of withdrawal in opiate addicts, and using it as anesthetic agent.

Definition

ChEBI: A quinazoline alkaloid that is a marine toxin isolated from fish such as puffer fish. It has been shown to exhibit potential neutotoxicity due to its ability to block voltage-gated sodium channels.

Biological Activity

Selective inhibitor of Na + channel conductance. Binding is reversible and of high affinity (K d = 1-10 nM). Blocks in a use-dependent manner.

storage

-20°C (desiccate)

Toxicity evaluation

TTX is a selective sodium channel blocker that can block nerve and muscle conductions; action potentials are blocked while resting membrane potentials and resting membrane resistance are not affected. TTX blocks axonal transmission by lowering the conductance of sodium at nodes of Ranvier. Vomiting occurs because the toxin can act directly at or near the chemoreceptor trigger zone. Respiratory depression is caused by either a specific action of tetrodotoxin on the brain’s respiratory center or because paralysis of respiratory nerves and muscles occurs.

Questions And Answer

Well-known Reagent Company Product Information

Supplier

WUHAN XINXINJIALI BIOTECHNOLOGY Co. LTD.

Telephone027-59223049 15807102573

Websitehttp://www.xxjltech.com/

Qingdao IniKem BioPharmaTech Co.,Ltd

Telephone0532-58268780

Websitehttp://www.inikem.com

J & K SCIENTIFIC LTD.

Telephone010-82848833 400-666-7788

Websitehttp://www.jkchemical.com

3B Pharmachem (Wuhan) International Co.,Ltd.

Telephone821-50328103-801 18930552037

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList13285/0.htm

Chemsky（shanghai）International Co.,Ltd.

Telephone021-50135380

Websitehttp://www.shchemsky.com

Sichuan Kulinan Technology Co., Ltd

Telephone400-1166-196 18981987031

Websitehttp://www.hx-r.com/

Thermo Fisher Scientific

Telephone800-810-5118

Websitehttp://www.thermo.com.cn

Beijing HuaMeiHuLiBiological Chemical

Telephone010-56205725

Websitehttp://www.huabeibiochem.com/

Haoyuan Chemexpress Co., Ltd.

Telephone021-58950125

Websitehttp://gb.chemexpress.com.cn

Shanghai Ruji Biology Technology Co., Ltd.

Telephone+86-21-65211385-8001 36031160

Websitehttp://www.chinaruji.com/

Shanghai Tauto Biotech Co., Ltd.

Telephone021-51320588

Websitehttp://www.tautobiotech.com/

Shanghai BeiZhuo Biotech Co., Ltd.

Telephone021-61119791,13386096464

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList16081/0.htm

Shanghai Meishui Chemical Technology Co., Ltd

Telephone021-60549325 18616193163

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList16215/0.htm

Shanghai JONLN Reagent Co., Ltd.

Telephone400-0066400 13621662912

Websitehttp://www.jonln.com

Kingfirst Chemical (Nanjing) Co.,Ltd

Telephone+86-025-84522992 84524602 13805186390

Websitehttp://www.kingfirstchem.com

BeiJing TOP Science Bio-Technology Co., Ltd.

Telephone+86-13439059536 +86-15201677815

Websitehttp://www.itopsci.com/

Changzhou Renaissance Chem Co. Ltd

Telephone86-519-86202821

Websitehttp://www.renaissance-chem.com

Suzhou yacoo science co.,Ltd

Telephone0512-87182056 18013166090

Websitehttp://www.yacoo.com.cn

1of4

Related Products

Send Inquriy

4368-28-9

Chemical Properties

Safety Data

Hazard Information

Chemical Properties

Uses

Uses

Definition

Biological Activity

storage

Toxicity evaluation

Questions And Answer

Description

References

Well-known Reagent Company Product Information

Supplier

Related Products