Chemical Properties
white to light beige crystalline powder or
Uses
Pyridinium p-Toluenesulfate is used in the synthesis of a subdomain of the cytochrome P450 BM3 enzyme, for use in screening systems for drug candidates.
Uses
As a co-catalyst with L-proline improved both yield and enantioselectivity of an asymmetric aldol condensation between dioxanones and aldehydes.1
Uses
Pyridinium p-Toluenesulfonate is used in the synthesis of a subdomain of the cytochrome P450 BM3 enzyme, for use in screening systems for drug candidates.
Flammability and Explosibility
Not classified
Synthesis
(2) 4-methylbenzenesulfonic acid (5 g, 0.029 mol) and anhydrous tetrahydrofuran (40 mL) were added to the reactor under nitrogen protection and stirred at room temperature. The reaction mixture was cooled to 0-5 °C. At this temperature, a tetrahydrofuran solution of pyridine (2.75 g, 0.035 mol) was slowly added dropwise for 20 to 30 min, followed by continued stirring for 30 min. After completion of the reaction, the reaction mixture was filtered under nitrogen atmosphere and the solid product was collected. The filter cake was washed with anhydrous tetrahydrofuran (5 mL), and then the wet filter cake was placed in a vacuum oven and dried at 45-50 °C for 4 h to obtain the pyridinium salt of 4-methylbenzenesulfonate. The yield of the product was 6 g, the yield was 82.19% and the purity was 100% by HPLC.
References
[1] Patent: CN106565521, 2017, A. Location in patent: Paragraph 0072-0075
[2] Patent: CN106565442, 2017, A. Location in patent: Paragraph 0065; 0066; 0067
[3] Patent: CN106632223, 2017, A. Location in patent: Paragraph 0069; 0070; 0071
[4] Patent: CN106349269, 2017, A. Location in patent: Paragraph 0073; 0074; 0075
[5] Synthetic Communications, 2013, vol. 43, # 21, p. 2906 - 2912
