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Tranilast

Tranilast Structure
Tranilast
  • CAS No.53902-12-8
  • Chemical Name:Tranilast
  • CBNumber:CB0289227
  • Molecular Formula:C18H17NO5
  • Formula Weight:327.33
  • MOL File:53902-12-8.mol
Tranilast Property
  • Melting point: :166.2-168.2 °C(lit.)
  • Boiling point: :465.23°C (rough estimate)
  • Density  :1.3185 (rough estimate)
  • refractive index  :1.5100 (estimate)
  • storage temp.  :2-8°C
  • solubility  :DMSO: 18 mg/mL
  • pka :3.47±0.36(Predicted)
  • form  :powder
  • color  :white to beige
  • Merck  :14,9570
  • InChIKey :NZHGWWWHIYHZNX-CSKARUKUSA-N
  • CAS DataBase Reference :53902-12-8(CAS DataBase Reference)
  • FDA UNII :HVF50SMY6E
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :22
  • Safety Statements  :26-36
  • WGK Germany  :3
  • RTECS  :DG8731000
  • Toxicity :LD50 in male, female mice, male, female rats (mg/kg): 780, 680, 1600, 1100 orally; 410, 385, 405, 395 i.p.; 2630, 2820, 3630, 3060 s.c. (Nakazawa, p 385)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements
Tranilast Price More Price(8)
  • Brand: Sigma-Aldrich
  • Product number: 616400-M
  • Product name : Tranilast
  • Purity: 
  • Packaging: 10mg-m
  • Price: $141
  • Updated: 2019/12/02
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: T0318
  • Product name : Tranilast
  • Purity: ≥98% (HPLC), powder
  • Packaging: 10mg
  • Price: $147
  • Updated: 2019/12/02
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: T2935
  • Product name : Tranilast
  • Purity: >98.0%(HPLC)(T)
  • Packaging: 1g
  • Price: $143
  • Updated: 2020/06/24
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: T2935
  • Product name : Tranilast
  • Purity: >98.0%(HPLC)(T)
  • Packaging: 5g
  • Price: $491
  • Updated: 2020/06/24
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 13044
  • Product name : Tranilast
  • Purity: ≥98%
  • Packaging: 5mg
  • Price: $15
  • Updated: 2020/06/24
  • Buy: Buy

Tranilast Chemical Properties,Usage,Production

  • Chemical Properties Pale Green Solid
  • Uses coronary vasodilator
  • Uses Tranilast is a compound that exhibits anti-inflammatory and immunomodulatory effects by inhibiting lipid mediator and cytokine release from inflammatory cells and interfering with PDGF- and TGF-β1-induced proliferation and migration of vascular medial smooth muscle cells. Tranilast suppresses production of prostaglandin D2 (IC50 = 0.1 mM), prostaglandin E2 (IC50 = ~1-20 μM), thromboxane B2 (IC50 = ~10-50 μM), TGF-β1 (IC50 = ~100-200 μM), and interleukin-8 (IC50 = ~100 μM) in in vitro models as well as attenuates of the proinflammatory activity of human monocytes. While originally marketed as an antiallergenic drug, the efficacy of tranilast in preventing restenosis after percutaneous coronary intervention has been tested in a large-scale clinical trial. Additionally, tranilast inhibits VEGF-induced angiogenetic activities (i.e., proliferation, migration and tube formation of vascular endothelial cells) with IC50 values of 22, 18 and 193 μM, which may prove therapeutic for various retinal diseases.[Cayman Chemical]
  • Uses Antiallergic drug, used to treat bronchial asthma, allergic rhinitis and atopic dermatitis.
  • Definition ChEBI: An amidobenzoic acid that is anthranilic acid in which one of the anilino hydrogens is replaced by a 3,4-dimethoxycinnamoyl group.
  • Biological Activity Antiallergic via inhibition of chemical mediator release from mast cells. Most recently shown to be an effective inhibitor of angiogenesis. Demonstrated to antagonize the effects of angiotensin II on human arteries, possibly by an interaction at the level of the AT 1 receptor.
Tranilast Preparation Products And Raw materials
Raw materials
Preparation Products
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53902-12-8, TranilastRelated Search:
  • 2-[[3-(3,4-DIMETHOXYPHENYL)-1-OXO-2-PROPENYL]AMINO] BENZOIC ACID
  • TRANILAST
  • 2-((3-(3,4-dimethoxyphenyl)-1-oxo-2-propenyl)amino)-benzoicaci
  • n-(3,4-dimethoxycinnamoyl)-anthranilicaci
  • n-5’
  • rizaben
  • SB-252218
  • N-(3',4'-DIMETHOXYCINNAMOYL)ANTHRANILIC ACID
  • 3,4-DAA, N-(3,4-Dimethoxycinnamoyl)anthranilic acid, Rizaben, SB-252218, 2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino] benzoic acid
  • Anthranilic acid, N-(3,4-dimethoxycinnamoyl)-
  • Benzoic acid, 2-[[3-(3,4-dimethoxyphenyl)-1-oxo-2-propenyl]amino]-
  • Tranilast(SB 252218)
  • 2-[[3-(3,4-DiMethoxyphenyl)-1-oxo-2-propen-1-yl]aMino]benzoic Acid
  • Tranpro
  • MK 341
  • Benzoicacid, 2-[[3-(3,4-diMethoxyphenyl)-1-oxo-2-propen-1-yl]aMino]-
  • (E)-2-(3-(3,4-dimethoxyphenyl)acrylamido)benzoic acid
  • (E)-2-(3-(3,5-dimethoxyphenyl)acrylamido)benzoic acid
  • Nano Liposomal Tranilast
  • Rizaben,MK 341,Tranpro
  • Tranilast - CAS 53902-12-8 - Calbiochem
  • 2-[[(E)-3-(3,4-dimethoxyphenyl)-1-oxoprop-2-enyl]amino]benzoate
  • 53902-12-8
  • C18H17NO5
  • Angiotensin
  • Angiogenesis and Metastasis
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • PEXID
  • Inhibitors