Tranilast suppliers

Tranilast

CAS:: 53902-12-8

MF:: C18H17NO5

MW:: 327.33

SecurityInformation

Symbol(GHS) ：: GHS07

Signal word ：: Warning

Hazard statements ：: H302

Precautionary statements ：: P264-P270-P301+P312-P501

PPE：: dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes ：: Xn

Risk Statements ：: 22

Safety Statements ：: 26-36

WGK Germany ：: 3

RTECS ：: DG8731000

HS Code ：: 2924.29.6250

Storage Class：: 11 - Combustible Solids

Hazard Classifications：: Acute Tox. 4 Oral

Toxicity：: LD50 in male, female mice, male, female rats (mg/kg): 780, 680, 1600, 1100 orally; 410, 385, 405, 395 i.p.; 2630, 2820, 3630, 3060 s.c. (Nakazawa, p 385)

Use：: Tranilast is a compound that exhibits anti-inflammatory and immunomodulatory effects by inhibiting lipid mediator and cytokine release from inflammatory cells and interfering with PDGF- and TGF-β1-induced proliferation and migration of vascular medial smooth muscle cells. Tranilast suppresses production of prostaglandin D2 (IC50 = 0.1 mM), prostaglandin E2 (IC50 = ~1-20 μM), thromboxane B2 (IC50 = ~10-50 μM), TGF-β1 (IC50 = ~100-200 μM), and interleukin-8 (IC50 = ~100 μM) in in vitro models as well as attenuates of the proinflammatory activity of human monocytes. While originally marketed as an antiallergenic drug, the efficacy of tranilast in preventing restenosis after percutaneous coronary intervention has been tested in a large-scale clinical trial. Additionally, tranilast inhibits VEGF-induced angiogenetic activities (i.e., proliferation, migration and tube formation of vascular endothelial cells) with IC50 values of 22, 18 and 193 μM, which may prove therapeutic for various retinal diseases.[Cayman Chemical]

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You can find Tranilast suppliers, manufacturers, and distributors from countries such as CHINA, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

career henan chemical co

Tranilast
Remarks: Purity: 99% | Package: 1kg
TEL: 0371-86658258
CHINA Reagent

BOC Sciences

Tranilast
Remarks: CustNote: Please reach out to us for more information about custom solutions.
TEL: +1-631-485-4226
UNITED STATES Trader

CONIER CHEM AND PHARMA LIMITED

tranilast
Remarks: Purity: 99% | Package: 1kg
CHINA Trader

SIMAGCHEM CORP

Tranilast
Remarks: Purity: 0.99 | Package: 1kg,5kg,25kgs,200kgs;bulk
TEL: +86-5922680277
CHINA Trader

TargetMol Chemicals Inc.

Tranilast
Remarks: Purity: 99.90% | Package: 5mg;36USD|10mg;50USD|25mg;61USD | CustNote: REAGENT;FOR LABORATORY USE ONLY
TEL: +1-781-999-5354
UNITED STATES Trader

$36.00

$50.00

$61.00

Hefei Hangang Pharmaceutical Technology Co., Ltd.